TY - JOUR
T1 - Heavy resistance training at retirement age induces 4-year lasting beneficial effects in muscle strength
T2 - a long-term follow-up of an RCT
AU - Bloch-Ibenfeldt, Mads
AU - Theil Gates, Anne
AU - Karlog, Karoline
AU - Demnitz, Naiara
AU - Kjaer, Michael
AU - Boraxbekk, Carl-Johan
N1 - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024
Y1 - 2024
N2 - OBJECTIVES: Muscle function and size decline with age, but long-term effects of resistance training in older adults are largely unknown. Here, we explored the long-lasting (3 years) effects of 1 year of supervised resistance training with heavy loads.METHODS: The LIve active Successful Ageing (LISA) study was a parallel group randomised controlled trial at a university hospital in Denmark. Older adults (n=451) at retirement age were randomised to 1 year of heavy resistance training (HRT), moderate-intensity training (MIT) or a non-exercising control group (CON). Primary outcome measure was leg extensor power. Secondary outcomes included maximal isometric quadriceps torque (isometric leg strength) and body composition (dual-energy X-ray absorptiometry (DXA)). Participants completed test procedures at baseline, following the 1-year intervention, and 2 and 4 years post study start.RESULTS: At the 4-year assessment, 369 participants attended (mean age=71 years, 61% women). The main finding was that across all four time points, there was a significant group×time interaction in isometric leg strength (F6,1049=8.607, p<0.001, η 2 =0.05). Individuals in HRT maintained baseline performance in isometric leg strength (Baseline: 149.7±51.5 Nm, 4 years: 151.5±51.1 Nm, t(1050)=1.005, p=1.00) while participants in CON and MIT decreased.CONCLUSION: In well-functioning older adults at retirement age, 1 year of HRT may induce long-lasting beneficial effects by preserving muscle function.TRIAL REGISTRATION NUMBER: NCT02123641.
AB - OBJECTIVES: Muscle function and size decline with age, but long-term effects of resistance training in older adults are largely unknown. Here, we explored the long-lasting (3 years) effects of 1 year of supervised resistance training with heavy loads.METHODS: The LIve active Successful Ageing (LISA) study was a parallel group randomised controlled trial at a university hospital in Denmark. Older adults (n=451) at retirement age were randomised to 1 year of heavy resistance training (HRT), moderate-intensity training (MIT) or a non-exercising control group (CON). Primary outcome measure was leg extensor power. Secondary outcomes included maximal isometric quadriceps torque (isometric leg strength) and body composition (dual-energy X-ray absorptiometry (DXA)). Participants completed test procedures at baseline, following the 1-year intervention, and 2 and 4 years post study start.RESULTS: At the 4-year assessment, 369 participants attended (mean age=71 years, 61% women). The main finding was that across all four time points, there was a significant group×time interaction in isometric leg strength (F6,1049=8.607, p<0.001, η 2 =0.05). Individuals in HRT maintained baseline performance in isometric leg strength (Baseline: 149.7±51.5 Nm, 4 years: 151.5±51.1 Nm, t(1050)=1.005, p=1.00) while participants in CON and MIT decreased.CONCLUSION: In well-functioning older adults at retirement age, 1 year of HRT may induce long-lasting beneficial effects by preserving muscle function.TRIAL REGISTRATION NUMBER: NCT02123641.
KW - Aging
KW - Body composition
KW - Exercise
KW - Skeletal muscle
KW - Training
UR - http://www.scopus.com/inward/record.url?scp=85196863656&partnerID=8YFLogxK
U2 - 10.1136/bmjsem-2024-001899
DO - 10.1136/bmjsem-2024-001899
M3 - Journal article
C2 - 38911477
SN - 2055-7647
VL - 10
SP - e001899
JO - BMJ Open Sport & Exercise Medicine
JF - BMJ Open Sport & Exercise Medicine
IS - 2
M1 - e001899
ER -