Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

Erik J Boll; Jakob Frimodt-Møller; Bente Olesen; Karen A Krogfelt; Carsten Struve

doi:10.1016/j.resmic.2016.02.002

Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

Erik J Boll, Jakob Frimodt-Møller, Bente Olesen, Karen A Krogfelt, Carsten Struve

Department of Clinical Microbiology

17 Citations (Scopus)

Abstract

Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are a major concern worldwide. There is an urgent need to identify bacterial factors promoting survival and persistence of these organisms in the nosocomial environment. Here, we describe the presence of a gene cluster, containing the Clp ATPase ClpK, within a collection of Danish ESBL-producing E. coli isolates. The cluster conferred thermoprotection upon the isolates, and thus might facilitate survival on medical devices exposed to semi-high temperatures in a hospital setting.

Original language	English
Journal	Veterinary Microbiology
Volume	167
Issue number	5
Pages (from-to)	345-9
Number of pages	5
ISSN	0378-1135
DOIs	https://doi.org/10.1016/j.resmic.2016.02.002
Publication status	Published - Jun 2016

Keywords

Cross Infection/microbiology
Denmark
Endopeptidase Clp/genetics
Environmental Microbiology
Escherichia coli/enzymology
Hospitals
Hot Temperature
Microbial Viability/radiation effects
Multigene Family
beta-Lactamases/secretion

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10.1016/j.resmic.2016.02.002

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title = "Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting",

abstract = "Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are a major concern worldwide. There is an urgent need to identify bacterial factors promoting survival and persistence of these organisms in the nosocomial environment. Here, we describe the presence of a gene cluster, containing the Clp ATPase ClpK, within a collection of Danish ESBL-producing E. coli isolates. The cluster conferred thermoprotection upon the isolates, and thus might facilitate survival on medical devices exposed to semi-high temperatures in a hospital setting. ",

keywords = "Cross Infection/microbiology, Denmark, Endopeptidase Clp/genetics, Environmental Microbiology, Escherichia coli/enzymology, Hospitals, Hot Temperature, Microbial Viability/radiation effects, Multigene Family, beta-Lactamases/secretion",

author = "Boll, \{Erik J\} and Jakob Frimodt-M{\o}ller and Bente Olesen and Krogfelt, \{Karen A\} and Carsten Struve",

year = "2016",

month = jun,

doi = "10.1016/j.resmic.2016.02.002",

language = "English",

volume = "167",

pages = "345--9",

journal = "Veterinary Microbiology",

issn = "0378-1135",

publisher = "Elsevier BV",

number = "5",

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TY - JOUR

T1 - Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

AU - Boll, Erik J

AU - Frimodt-Møller, Jakob

AU - Olesen, Bente

AU - Krogfelt, Karen A

AU - Struve, Carsten

PY - 2016/6

Y1 - 2016/6

N2 - Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are a major concern worldwide. There is an urgent need to identify bacterial factors promoting survival and persistence of these organisms in the nosocomial environment. Here, we describe the presence of a gene cluster, containing the Clp ATPase ClpK, within a collection of Danish ESBL-producing E. coli isolates. The cluster conferred thermoprotection upon the isolates, and thus might facilitate survival on medical devices exposed to semi-high temperatures in a hospital setting.

AB - Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are a major concern worldwide. There is an urgent need to identify bacterial factors promoting survival and persistence of these organisms in the nosocomial environment. Here, we describe the presence of a gene cluster, containing the Clp ATPase ClpK, within a collection of Danish ESBL-producing E. coli isolates. The cluster conferred thermoprotection upon the isolates, and thus might facilitate survival on medical devices exposed to semi-high temperatures in a hospital setting.

KW - Cross Infection/microbiology

KW - Denmark

KW - Endopeptidase Clp/genetics

KW - Environmental Microbiology

KW - Escherichia coli/enzymology

KW - Hospitals

KW - Hot Temperature

KW - Microbial Viability/radiation effects

KW - Multigene Family

KW - beta-Lactamases/secretion

UR - https://www.scopus.com/pages/publications/84971427157

U2 - 10.1016/j.resmic.2016.02.002

DO - 10.1016/j.resmic.2016.02.002

M3 - Journal article

C2 - 26946311

SN - 0378-1135

VL - 167

SP - 345

EP - 349

JO - Veterinary Microbiology

JF - Veterinary Microbiology

IS - 5

ER -

Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

Abstract

Keywords

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