Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Heart murmur and N-terminal pro-brain natriuretic peptide as predictors of death in 2977 consecutive hospitalized patients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Aldosterone Blockade Added to Renin-Angiotensin System Blockade to Reduce Albuminuria-A Path for Improved Renoprotection?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. De la levure aux maladies neurodégénératives : dix ans d'exploration des pathologies de la dynamique mitochondriale

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Coagulation parameters in the newborn and infant - the Copenhagen Baby Heart and COMPARE studies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lipoprotein(a) levels at birth and in early childhood: The COMPARE Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ticagrelor and the risk of Staphylococcus aureus bacteraemia and other infections

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Biomarkers of Cerebral Injury for Prediction of Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Little is known about the prognostic importance of murmur in unselected patients. It is difficult to distinguish between innocent and significant murmurs. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and BNP have recently been shown to be useful in small series of patients with valvular heart disease. We wanted to test whether murmur predicts mortality in unselected patients admitted to the hospital and whether NT-pro-BNP is capable of distinguishing between innocent and significant murmurs.

METHODS: Consecutive patients (n = 2977) older than 40 years admitted to a local hospital were studied. Auscultation, echocardiography were performed and levels of natriuretic peptides were measured.

RESULTS: A total of 21.8% of the 2977 patients had a murmur. After adjusting for sex and age there was a significant difference in the one-year mortality of patients with and without murmur (OR = 1.57, 95% CI = 1.27-1.94). NT-pro-BNP gave additional prognostic information for both patients with and without murmurs. Presence of a murmur was an independent predictor of 1-year mortality (OR = 1.36, 95% CI = 1.03-1.80) in a multivariate analysis. In patients with a murmur but normal NT-pro-BNP, discovery of valvular heart disease by echocardiography yielded no additional prognostic information.

CONCLUSIONS: Detection of a cardiac murmur during routine medical examination of hospitalized patients is associated with increased risk of death within a year. A blood test for NT-pro-BNP gives significant additional prognostic information of a murmur and could obviate the need for echocardiography in selected patients with a murmur and normal NT-pro-BNP for whom surgery is not feasible.

Original languageEnglish
JournalMedecine/Sciences
Volume335
Issue number6
Pages (from-to)444-50
Number of pages7
ISSN0002-9629
DOIs
Publication statusPublished - Jun 2008

    Research areas

  • Aged, Aged, 80 and over, Echocardiography, Female, Heart Auscultation, Heart Murmurs/diagnosis, Heart Valve Diseases/complications, Hospitalization, Humans, Male, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Predictive Value of Tests, Prognosis, Regression Analysis, Retrospective Studies, Survival Analysis, Time Factors

ID: 61885175