Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Health-Related Quality of Life in Patients with Philadelphia-Negative Myeloproliferative Neoplasms: A Nationwide Population-Based Survey in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Long-Term Follow-Up and Predictors of Functional Outcome after Surgery for Spinal Meningiomas: A Population-Based Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. TAM Receptor Inhibition-Implications for Cancer and the Immune System

    Research output: Contribution to journalReviewpeer-review

  1. Chronic productive cough and inhalant occupational exposure-a study of the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival

    Research output: Contribution to journalLetterpeer-review

  3. Drug-drug interaction between warfarin and statins: A Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Previous studies have clarified that many patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) have burdensome symptom profiles and accordingly impaired functioning and quality of life (QoL). In Denmark, all MPN patients are affiliated with public hospitals and because of a healthcare system financed by taxpayers these patients do not have any financial costs related to the hematological disease. Diagnoses are recorded for all patients in hospitals, and diagnosis codes are communicated to the National Patient Register (NPR). Owing to this, it was possible to contribute to the elucidation of Philadelphia-negative MPN patients' health-related quality of life (HRQoL), by conducting a nationwide, population-based, cross-sectional HRQoL survey of these patients with cost-free access to the best available, suitable medical treatment. The survey contained validated questionnaires covering functioning, symptom burden, symptom profile, QoL, and additional questions on lifestyle. Information on comorbid diagnoses was obtained from the NPR. The participants' HRQoL was compared to the general population. Moreover, differences in HRQoL across essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN participants were investigated, adjusted for age, sex, comorbidity, and lifestyle. To the best of our knowledge this is the first survey of HRQoL in patients with unclassifiable MPN. A total of 2228 Philadelphia-negative MPN patients participated. The participants reported their HRQoL to be inferior to the general population, but the difference was minor. The differences in HRQoL across groups of participants with different MPN subtypes were subtle. Fatigue and sexual problems were prevalent and burdensome. Overall, participants reported a slightly healthier lifestyle compared to the general population.

Original languageEnglish
Article number3565
Issue number12
Pages (from-to)1-17
Number of pages17
Publication statusPublished - Dec 2020

    Research areas

  • fatigue, functioning, health-related quality of life, lifestyle, myeloproliferative neoplasm, patient-reported outcome, symptom burden, symptoms, Health-related quality of life, Symptom burden, Fatigue, Patient-reported outcome, Functioning, Lifestyle, Myeloproliferative neoplasm, Symptoms

ID: 61530802