Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Health-related quality of life in inflammatory bowel disease in a Danish population-based inception cohort

Research output: Contribution to journalJournal articleResearchpeer-review


  1. ECCO topical review: Refractory Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Crohn's disease (CD) and ulcerative colitis (UC) are associated with reduced health-related quality of life (HRQoL), but findings differ between studies. The aim of this study was to analyse the impact of disease activity and social factors on HRQoL.

Method: A total of 513 patients diagnosed with UC and CD between 2003 and 2004, in a population-based setting, were followed for 7 years. HRQoL was assessed using the Short Form-12, the Short Inflammatory Bowel Disease (IBD) Questionnaire (SIBDQ), the Work Productivity and Activity Impairment Questionnaire: General Health and a national health survey. Associations were assessed using multiple linear regressions.

Results: A total of 185 of the eligible patients (UC: 107 (50.2%) and CD: 78 (50.3%)) were included. No differences in disease-specific or generic HRQoL were found between CD and UC patients, and IBD patients did not differ compared with the background population. The majority of CD (73.1%) and UC (85.0%) patients had 'good' disease-specific HRQoL using the SIBDQ. Unemployment for ≥ 3 months occurred more in CD vs UC patients(30.6 vs 15.5%, p = 0.03); however, sick leave for ≥ 3 months did not differ significantly (17.4 vs 11.4%, p = 0.4). Using multiple linear regressions, unemployment, sick leave and disease activity were the factors most frequently associated with reduced HRQoL.

Conclusion: In a population-based cohort with 7 years of follow-up, HRQoL did not differ between patients and the background population.

Original languageEnglish
JournalUnited European Gastroenterology Journal
Issue number7
Pages (from-to)942-954
Number of pages13
Publication statusPublished - Aug 2019

    Research areas

  • cohort study, Crohn's disease, Inflammatory bowel disease, observational study, patient-reported outcome, quality of life, ulcerative colitis

ID: 57822521