Healthcare Resource Utilization in Patients with Myeloproliferative Neoplasms: A Danish Nationwide Matched Cohort Study

Sarah Friis Christensen, Lise Skovgaard Svingel, Anders Kjaersgaard, Anna Stenling, Bianka Darvalics, Björn Paulsson, Christen Lykkegaard Andersen, Christian Fynbo Christiansen, Jesper Stentoft, Jørn Starklint, Marianne Tang Severinsen, Mette Borg Clausen, Morten Hagemann Hilsøe, Hans Carl Hasselbalch, Henrik Frederiksen, Ellen Margrethe Mikkelsen, Marie Bak


Few studies have assessed healthcare resource utilization (HRU) in patients with Philadelphia-negative myeloproliferative neoplasms (MPN) using a matched cohort design. Further, no detailed assessment of HRU in the years preceding an MPN diagnosis exists. We conducted a registry-based nationwide Danish cohort study, including patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN diagnosed between January 2010 and December 2016. HRU data were summarized annually from 2 years before MPN diagnosis until emigration, death, or end of study (December 2017). We included 3342 MPN patients and 32 737 comparisons without an MPN diagnosis, matched on sex, age, region of residence, and level of education. During the study period, the difference in HRU (rate ratio) between patients and matched comparisons ranged from 1.0 to 1.5 for general practitioner contacts, 0.9 to 2.2 for hospitalizations, 0.9 to 3.8 for inpatient days, 1.0 to 4.0 for outpatient visits, 1.3 to 2.1 for emergency department visits, and 1.0 to 4.1 for treatments/examinations. In conclusion, MPN patients had overall higher HRU than the matched comparisons throughout the follow-up period (maximum 8 years). Further, MPN patients had substantially increased HRU in both the primary and secondary healthcare sector in the 2 years preceding the diagnosis.

Original languageEnglish
JournalEuropean Journal of Haematology
Issue number5
Pages (from-to)526-541
Number of pages16
Publication statusPublished - Nov 2022


  • Cohort Studies
  • Delivery of Health Care
  • Denmark/epidemiology
  • Humans
  • Myeloproliferative Disorders/diagnosis
  • Polycythemia Vera/complications
  • health resources
  • hospitalization
  • case–control studies
  • ambulatory care
  • registries
  • healthcare costs
  • early diagnosis
  • myeloproliferative disorder
  • epidemiology
  • general practice


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