Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Towards precision medicine in diabetes? A critical review of glucotypes

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Copy number variation of KIR genes influences HIV-1 control

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Modulatory Role of Serotonin on Human Impulsive Aggression

    Research output: Contribution to journalReviewResearchpeer-review

  2. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Structural brain abnormalities associated with cognitive impairments in bipolar disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Default mode network functional connectivity negatively associated with trait openness to experience

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Cerebrospinal fluid (CSF) flow through the brain parenchyma is facilitated by the astrocytic water channel aquaporin 4 (AQP4). Homeostatically regulated electroencephalographic (EEG) slow waves are a hallmark of deep non-rapid eye movement (NREM) sleep and have been implicated in the regulation of parenchymal CSF flow and brain clearance. The human AQP4 gene harbors several single nucleotide polymorphisms (SNPs) associated with AQP4 expression, brain-water homeostasis, and neurodegenerative diseases. To date, their role in sleep-wake regulation is unknown. To investigate whether functional variants in AQP4 modulate human sleep, nocturnal EEG recordings and cognitive performance were investigated in 123 healthy participants genotyped for a common eight-SNP AQP4-haplotype. We show that this AQP4-haplotype is associated with distinct modulations of NREM slow wave energy, strongest in early sleep and mirrored by changes in sleepiness and reaction times during extended wakefulness. The study provides the first human evidence for a link between AQP4, deep NREM sleep, and cognitive consequences of prolonged wakefulness.

Original languageEnglish
Article numbere3000623
JournalP L o S Biology
Volume18
Issue number5
Pages (from-to)e3000623
ISSN1544-9173
DOIs
Publication statusPublished - May 2020

    Research areas

  • Aquaporin 4/genetics, Electroencephalography, Haplotypes, Healthy Volunteers, Homeostasis, Humans, Sleep, Slow-Wave/genetics, Wakefulness

ID: 60965535