Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Hand eczema, atopic dermatitis and filaggrin mutations in adult Danes: a registry-based study assessing risk of disability pension

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Incidence rates of occupational contact dermatitis in Denmark between 2007 and 2018 - A population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Aluminium contact allergy without vaccination granulomas: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. Nickel release from metallic earrings: A survey of the Danish market and validation of the nickel spot test

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Memory T helper cells identify patients with nickel, cobalt, and chromium metal allergy

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Incidence rates of occupational contact dermatitis in Denmark between 2007 and 2018 - A population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Thyroid function in COVID-19 and the association with cytokine levels and mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Does Subclinical Hypothyroidism Add Any Symptoms? evidence from a Danish population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Atopic dermatitis and hand eczema often impair the ability of people to work. Only a few studies have investigated whether individuals with loss-of-function filaggrin gene (FLG) mutations, who often have severe and early onset of dermatitis, experience occupational consequences.

OBJECTIVE: To investigate the personal consequences of having atopic dermatitis and/or hand eczema and FLG mutations.

METHOD: Adult Danes from the general population (n = 3247) and patients with atopic dermatitis and/or hand eczema (n = 496) were genotyped for common FLG mutations, and completed a questionnaire about skin symptoms and hand eczema. Socioeconomic variables, including disability pension, and information on work in risk occupations were retrieved from national registries. The reasons for granting disability pension were unknown.

RESULTS: Disability pension was associated with hand eczema in the general population, especially among individuals with a history of atopic dermatitis. Moreover, self-reported hand eczema and atopic dermatitis were associated with particularly high risk of disability pension among FLG mutation carriers [odds ratio (OR) 4.02 and 95% confidence interval (CI): 1.15-14.11; and OR 6.01 and 95%CI: 2.37-15.34, respectively]. Furthermore, 60% of the FLG mutation carriers with atopic dermatitis who developed hand eczema had experienced symptoms before adulthood.

CONCLUSION: In the general population, self-reported hand eczema and atopic dermatitis, particularly in individuals with a genetically impaired skin barrier, were associated with disability pension, suggesting that FLG mutations carriers with a history of atopic dermatitis and hand eczema could benefit from early attention with respect to choice of occupation.

Original languageEnglish
JournalContact Dermatitis
Volume77
Issue number2
Pages (from-to)95-105
Number of pages11
ISSN0105-1873
DOIs
Publication statusPublished - Aug 2017

    Research areas

  • Journal Article

ID: 51553233