Hair metabolomics: identification of fetal compromise provides proof of concept for biomarker discovery

Karolina Sulek, Ting Li Han, Silas G.ranato Villas-Boas, David S.cott Wishart, Shu E. Soh, Kenneth Kwek, Peter D.avid Gluckman, Yap Seng Chong, Louise C.laire Kenny, Philip N.ewton Baker

69 Citations (Scopus)

Abstract

Analysis of the human metabolome has yielded valuable insights into health, disease and toxicity. However, the metabolic profile of complex biological fluids such as blood is highly dynamic and this has limited the discovery of robust biomarkers. Hair grows relatively slowly, and both endogenous compounds and environmental exposures are incorporated from blood into hair during growth, which reflects the average chemical composition over several months. We used hair samples to study the metabolite profiles of women with pregnancies complicated by fetal growth restriction (FGR) and healthy matched controls. We report the use of GC-MS metabolite profiling of hair samples for biomarker discovery. Unsupervised statistical analysis showed complete discrimination of FGR from controls based on hair composition alone. A predictive model combining 5 metabolites produced an area under the receiver-operating curve of 0.998. This is the first study of the metabolome of human hair and demonstrates that this biological material contains robust biomarkers, which may lead to the development of a sensitive diagnostic tool for FGR, and perhaps more importantly, to stable biomarkers for a range of other diseases.

Original languageEnglish
JournalTheranostics
Volume4
Issue number9
Pages (from-to)953-959
Number of pages7
ISSN1838-7640
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • biomarker
  • fetal growth restriction
  • GC-MS.
  • hair
  • metabolite profiling

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