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Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

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@article{31853e3154c44e899450435b08d6add8,
title = "Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives",
abstract = "OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1{\%} (95{\%}CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.",
author = "Klara Coello and Klaus Munkholm and Flemming Nielsen and Maj Vinberg and Kessing, {Lars Vedel}",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2019",
month = "9",
day = "18",
doi = "10.1016/j.psyneuen.2018.09.020",
language = "English",
volume = "99",
pages = "183--190",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

AU - Coello, Klara

AU - Munkholm, Klaus

AU - Nielsen, Flemming

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2019/9/18

Y1 - 2019/9/18

N2 - OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1% (95%CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.

AB - OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1% (95%CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.

U2 - 10.1016/j.psyneuen.2018.09.020

DO - 10.1016/j.psyneuen.2018.09.020

M3 - Journal article

VL - 99

SP - 183

EP - 190

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 55376995