Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Habitual sleep disturbances and migraine: a Mendelian randomization study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The impact of gender, puberty, and pregnancy in patients with POLG disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Consistent improvement with eculizumab across muscle groups in myasthenia gravis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Responsiveness of outcome measures in myotonic dystrophy type 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Explicit Diagnostic Criteria for Transient Ischemic Attacks Used in the Emergency Department Are Highly Sensitive and Specific

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Functional gene networks reveal distinct mechanisms segregating in migraine families

    Research output: Contribution to journalJournal articleResearchpeer-review

  • International Headache Genetics Consortium
View graph of relations

OBJECTIVE: Sleep disturbances are associated with increased risk of migraine, however the extent of shared underlying biology and the direction of causal relationships between these traits is unclear. Delineating causality between sleep patterns and migraine may offer new pathophysiologic insights and inform subsequent intervention studies. Here, we used genetic approaches to test for shared genetic influences between sleep patterns and migraine, and to test whether habitual sleep patterns may be causal risk factors for migraine and vice versa.

METHODS: To quantify genetic overlap, we performed genome-wide genetic correlation analyses using genome-wide association studies of nine sleep traits in the UK Biobank (n ≥ 237,627), and migraine from the International Headache Genetics Consortium (59,674 cases and 316,078 controls). We then tested for potential causal effects between sleep traits and migraine using bidirectional, two-sample Mendelian randomization.

RESULTS: Seven sleep traits demonstrated genetic overlap with migraine, including insomnia symptoms (rg = 0.29, P < 10-31 ) and difficulty awakening (rg = 0.11, P < 10-4 ). Mendelian randomization analyses provided evidence for potential causal effects of difficulty awakening on risk of migraine (OR [95% CI] = 1.37 [1.12-1.68], P = 0.002), and nominal evidence that liability to insomnia symptoms increased the risk of migraine (1.09 [1.02-1.16], P = 0.02). In contrast, there was minimal evidence for an effect of migraine liability on sleep patterns or disturbances.

INTERPRETATION: These data support a shared genetic basis between several sleep traits and migraine, and support potential causal effects of difficulty awakening and insomnia symptoms on migraine risk. Treatment of sleep disturbances may therefore be a promising clinical intervention in the management of migraine.

Original languageEnglish
JournalAnnals of Clinical and Translational Neurology
Volume7
Issue number12
Pages (from-to)2370-2380
ISSN2328-9503
DOIs
Publication statusE-pub ahead of print - 2021

ID: 61782096