Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Clinical forensic medicine in Eastern Denmark: Organisation and assessments

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Brain function and blood flow

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genetic association study of childhood aggression across raters, instruments, and age

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The trans-ancestral genomic architecture of glycemic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  • BIOS Consortium
View graph of relations

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

Original languageEnglish
JournalScientific American
Volume5
Issue number9
Pages (from-to)eaaw3095
ISSN0036-8733
DOIs
Publication statusPublished - Sep 2019

Bibliographical note

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

ID: 59066478