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Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

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Harvard

Jorsal, T, Christensen, MM, Mortensen, B, Nygaard, EB, Zhang, C, Rigbolt, K, Wandall, E, Langholz, E, Friis, S, Worm, D, Floyd, A, Helgstrand, F, Støving, RK, Aldries, AR, Juhl, CB, Østergaard, T, Rydborg, T, Forman, JL, Sørensen, F, Schmidt, T, Falkenhahn, M, Musholt, PB, Theis, S, Larsen, PJ, Rehfeld, JF, Vrang, N, Jelsing, J, Vilsbøll, T & Knop, FK 2020, 'Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery', Obesity (Silver Spring, Md.), vol. 28, no. 11, pp. 2163-2174. https://doi.org/10.1002/oby.22973

APA

CBE

Jorsal T, Christensen MM, Mortensen B, Nygaard EB, Zhang C, Rigbolt K, Wandall E, Langholz E, Friis S, Worm D, Floyd A, Helgstrand F, Støving RK, Aldries AR, Juhl CB, Østergaard T, Rydborg T, Forman JL, Sørensen F, Schmidt T, Falkenhahn M, Musholt PB, Theis S, Larsen PJ, Rehfeld JF, Vrang N, Jelsing J, Vilsbøll T, Knop FK. 2020. Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery. Obesity (Silver Spring, Md.). 28(11):2163-2174. https://doi.org/10.1002/oby.22973

MLA

Vancouver

Author

Jorsal, Tina ; Christensen, Marie M ; Mortensen, Brynjulf ; Nygaard, Eva B ; Zhang, Chen ; Rigbolt, Kristoffer ; Wandall, Erik ; Langholz, Ebbe ; Friis, Steffen ; Worm, Dorte ; Floyd, Andrea ; Helgstrand, Frederik ; Støving, René K ; Aldries, Alin R ; Juhl, Claus B ; Østergaard, Torben ; Rydborg, Thomas ; Forman, Julie L ; Sørensen, Frederik ; Schmidt, Torsten ; Falkenhahn, Mechthilde ; Musholt, Petra B ; Theis, Stefan ; Larsen, Philip J ; Rehfeld, Jens F ; Vrang, Niels ; Jelsing, Jacob ; Vilsbøll, Tina ; Knop, Filip K. / Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery. In: Obesity (Silver Spring, Md.). 2020 ; Vol. 28, No. 11. pp. 2163-2174.

Bibtex

@article{e19b98c3fd5b4ffca2bd57c92a790ad3,
title = "Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery",
abstract = "OBJECTIVE: Changes in the secretion of gut-derived peptide hormones have been associated with the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. In this study, the effects of RYGB on anthropometrics, postprandial plasma hormone responses, and mRNA expression in small intestinal mucosa biopsy specimens before and after RYGB were evaluated.METHODS: In a cross-sectional study, 20 individuals with obesity undergoing RYGB underwent mixed meal tests and upper enteroscopy with retrieval of small intestinal mucosa biopsy specimens 3 months before and after surgery. Concentrations of circulating gut and pancreatic hormones during mixed meal tests as well as full mRNA sequencing of biopsy specimens were evaluated.RESULTS: RYGB-induced improvements of body weight and composition, insulin resistance, and circulating cholesterols were accompanied by significant changes in postprandial plasma responses of pancreatic and gut hormones. Global gene expression analysis of biopsy specimens identified 2,437 differentially expressed genes after RYGB, including changes in genes that encode prohormones and G protein-coupled receptors.CONCLUSIONS: RYGB affects the transcription of a wide range of genes, indicating that the observed beneficial metabolic effects of RYGB may rely on a changed expression of several genes in the gut. RYGB-induced changes in the expression of genes encoding signaling peptides and G protein-coupled receptors may disclose new gut-derived treatment targets against obesity and diabetes.",
author = "Tina Jorsal and Christensen, {Marie M} and Brynjulf Mortensen and Nygaard, {Eva B} and Chen Zhang and Kristoffer Rigbolt and Erik Wandall and Ebbe Langholz and Steffen Friis and Dorte Worm and Andrea Floyd and Frederik Helgstrand and St{\o}ving, {Ren{\'e} K} and Aldries, {Alin R} and Juhl, {Claus B} and Torben {\O}stergaard and Thomas Rydborg and Forman, {Julie L} and Frederik S{\o}rensen and Torsten Schmidt and Mechthilde Falkenhahn and Musholt, {Petra B} and Stefan Theis and Larsen, {Philip J} and Rehfeld, {Jens F} and Niels Vrang and Jacob Jelsing and Tina Vilsb{\o}ll and Knop, {Filip K}",
note = "{\textcopyright} 2020 The Obesity Society.",
year = "2020",
month = nov,
doi = "10.1002/oby.22973",
language = "English",
volume = "28",
pages = "2163--2174",
journal = "Obesity",
issn = "1930-7381",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

AU - Jorsal, Tina

AU - Christensen, Marie M

AU - Mortensen, Brynjulf

AU - Nygaard, Eva B

AU - Zhang, Chen

AU - Rigbolt, Kristoffer

AU - Wandall, Erik

AU - Langholz, Ebbe

AU - Friis, Steffen

AU - Worm, Dorte

AU - Floyd, Andrea

AU - Helgstrand, Frederik

AU - Støving, René K

AU - Aldries, Alin R

AU - Juhl, Claus B

AU - Østergaard, Torben

AU - Rydborg, Thomas

AU - Forman, Julie L

AU - Sørensen, Frederik

AU - Schmidt, Torsten

AU - Falkenhahn, Mechthilde

AU - Musholt, Petra B

AU - Theis, Stefan

AU - Larsen, Philip J

AU - Rehfeld, Jens F

AU - Vrang, Niels

AU - Jelsing, Jacob

AU - Vilsbøll, Tina

AU - Knop, Filip K

N1 - © 2020 The Obesity Society.

PY - 2020/11

Y1 - 2020/11

N2 - OBJECTIVE: Changes in the secretion of gut-derived peptide hormones have been associated with the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. In this study, the effects of RYGB on anthropometrics, postprandial plasma hormone responses, and mRNA expression in small intestinal mucosa biopsy specimens before and after RYGB were evaluated.METHODS: In a cross-sectional study, 20 individuals with obesity undergoing RYGB underwent mixed meal tests and upper enteroscopy with retrieval of small intestinal mucosa biopsy specimens 3 months before and after surgery. Concentrations of circulating gut and pancreatic hormones during mixed meal tests as well as full mRNA sequencing of biopsy specimens were evaluated.RESULTS: RYGB-induced improvements of body weight and composition, insulin resistance, and circulating cholesterols were accompanied by significant changes in postprandial plasma responses of pancreatic and gut hormones. Global gene expression analysis of biopsy specimens identified 2,437 differentially expressed genes after RYGB, including changes in genes that encode prohormones and G protein-coupled receptors.CONCLUSIONS: RYGB affects the transcription of a wide range of genes, indicating that the observed beneficial metabolic effects of RYGB may rely on a changed expression of several genes in the gut. RYGB-induced changes in the expression of genes encoding signaling peptides and G protein-coupled receptors may disclose new gut-derived treatment targets against obesity and diabetes.

AB - OBJECTIVE: Changes in the secretion of gut-derived peptide hormones have been associated with the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. In this study, the effects of RYGB on anthropometrics, postprandial plasma hormone responses, and mRNA expression in small intestinal mucosa biopsy specimens before and after RYGB were evaluated.METHODS: In a cross-sectional study, 20 individuals with obesity undergoing RYGB underwent mixed meal tests and upper enteroscopy with retrieval of small intestinal mucosa biopsy specimens 3 months before and after surgery. Concentrations of circulating gut and pancreatic hormones during mixed meal tests as well as full mRNA sequencing of biopsy specimens were evaluated.RESULTS: RYGB-induced improvements of body weight and composition, insulin resistance, and circulating cholesterols were accompanied by significant changes in postprandial plasma responses of pancreatic and gut hormones. Global gene expression analysis of biopsy specimens identified 2,437 differentially expressed genes after RYGB, including changes in genes that encode prohormones and G protein-coupled receptors.CONCLUSIONS: RYGB affects the transcription of a wide range of genes, indicating that the observed beneficial metabolic effects of RYGB may rely on a changed expression of several genes in the gut. RYGB-induced changes in the expression of genes encoding signaling peptides and G protein-coupled receptors may disclose new gut-derived treatment targets against obesity and diabetes.

U2 - 10.1002/oby.22973

DO - 10.1002/oby.22973

M3 - Journal article

C2 - 33150746

VL - 28

SP - 2163

EP - 2174

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 11

ER -

ID: 61205894