Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Accepted/In press

Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Gastric Residual to Predict Necrotizing Enterocolitis in Preterm Piglets As Models for Infants

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Repeated Metabolic Balance Studies in Patients With Short Bowel Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. How to safeguard the brain of extremely preterm infants?

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Central data monitoring in the multicentre randomised SafeBoosC-III trial - a pragmatic approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The effect of early probiotic exposure on the preterm infant gut microbiome development

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Aerosol generation by respiratory support of neonates may be low

    Research output: Contribution to journalComment/debateResearchpeer-review

View graph of relations

Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. This pilot trial tests whether the supplement type, BC or donor human milk (DM), affects gut colonization in preterm infants during the first week of life. Methods: On day 7, fecal samples were collected from preterm infants (n = 24) fed BC or DM as a supplement to MM. The gut microbiome (GM) was analyzed by 16S ribosomal RNA amplicon sequencing. Correlations between the relative abundance of specific bacterial taxa and blood chemistry variables, including amino acids, were explored. Results: BC-supplemented infants showed a lower relative abundance of the families Lactobacillaceae and Enterococcaceae than DM infants. Planococcaceae were more abundant in infants delivered by cesarean birth vs vaginally. The relative abundance of bacterial families, specifically Enterobacteriaceae, correlated negatively with plasma levels of multiple essential and nonessential amino acids (valine, isoleucine, lysine, histidine, and arginine). Conclusion: The nature of nutrition supplements (BC or DM) just after birth may affect GM development and nutrient metabolism in the neonatal period of preterm infants. The exploratory nature of our study calls for confirmation of these results and their possible long-term clinical implications for preterm infants.

Original languageEnglish
JournalJournal of Parenteral and Enteral Nutrition
ISSN0148-6071
DOIs
Publication statusAccepted/In press - 2021

Bibliographical note

Funding Information:
This work is financially supported by the Innovation Fund Denmark under the Project NEOMUNE (Grant 12–132401 to Per Torp Sangild). Ping‐Ping Jiang received support from the Sun Yat‐sen University (2017181).

Publisher Copyright:
© 2021 American Society for Parenteral and Enteral Nutrition

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • bovine colostrum, fecal microbiome, feeding type, preterm infants

ID: 67283313