Gruppe B-streptokokker hos nyfødte og i de første tre levemåneder

Ida Nikoline Mandic; Victoria Elizabeth de Knegt; Hristo Stanchev; Tine Brink Henriksen; Emma Louise Malchau Carlsen; Maren Johanne Heilskov Rytter

doi:10.61409/V01240022

Gruppe B-streptokokker hos nyfødte og i de første tre levemåneder

Translated title of the contribution: Group B streptococci in newborns in the first three months of life

Ida Nikoline Mandic, Victoria Elizabeth de Knegt, Hristo Stanchev, Tine Brink Henriksen, Emma Louise Malchau Carlsen, Maren Johanne Heilskov Rytter

Department of Neonatology

1 Citation (Scopus)

Abstract

Group B Streptococcus (GBS) disease in neonates occurs in two forms: early-onset disease (EOD), (day 0-6), and late-onset disease (LOD), (day 7-90). This review investigates that risk-based intrapartum screening and antibiotics have reduced the incidence of EOD, but not LOD, in Denmark. No clinical or laboratory tests can rule out GBS disease at symptom onset. Thus, a high proportion of uninfected infants receive antibiotics, although this varies widely, and may be reduced by strategies of antibiotic stewardship. A future GBS vaccine for pregnant women may potentially reduce disease burden and antibiotic exposure.

Translated title of the contribution	Group B streptococci in newborns in the first three months of life
Original language	Danish
Article number	V01240022
Journal	Ugeskrift for Laeger
Volume	186
Issue number	26
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V01240022
Publication status	Published - 24 Jun 2024

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10.61409/V01240022Licence: CC BY-NC-ND

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@article{d67d07e9bc6f4a78adbfc59cf954604f,

title = "Gruppe B-streptokokker hos nyf{\o}dte og i de f{\o}rste tre levem{\aa}neder",

abstract = "Group B Streptococcus (GBS) disease in neonates occurs in two forms: early-onset disease (EOD), (day 0-6), and late-onset disease (LOD), (day 7-90). This review investigates that risk-based intrapartum screening and antibiotics have reduced the incidence of EOD, but not LOD, in Denmark. No clinical or laboratory tests can rule out GBS disease at symptom onset. Thus, a high proportion of uninfected infants receive antibiotics, although this varies widely, and may be reduced by strategies of antibiotic stewardship. A future GBS vaccine for pregnant women may potentially reduce disease burden and antibiotic exposure.",

keywords = "Humans, Streptococcal Infections/diagnosis, Infant, Newborn, Streptococcus agalactiae/isolation \& purification, Anti-Bacterial Agents/therapeutic use, Female, Pregnancy, Denmark/epidemiology, Pregnancy Complications, Infectious/diagnosis, Infant, Streptococcal Vaccines/administration \& dosage, Infectious Disease Transmission, Vertical/prevention \& control",

author = "Mandic, \{Ida Nikoline\} and \{de Knegt\}, \{Victoria Elizabeth\} and Hristo Stanchev and Henriksen, \{Tine Brink\} and Carlsen, \{Emma Louise Malchau\} and Rytter, \{Maren Johanne Heilskov\}",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2024",

month = jun,

day = "24",

doi = "10.61409/V01240022",

language = "Dansk",

volume = "186",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Gruppe B-streptokokker hos nyfødte og i de første tre levemåneder

AU - Mandic, Ida Nikoline

AU - de Knegt, Victoria Elizabeth

AU - Stanchev, Hristo

AU - Henriksen, Tine Brink

AU - Carlsen, Emma Louise Malchau

AU - Rytter, Maren Johanne Heilskov

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2024/6/24

Y1 - 2024/6/24

N2 - Group B Streptococcus (GBS) disease in neonates occurs in two forms: early-onset disease (EOD), (day 0-6), and late-onset disease (LOD), (day 7-90). This review investigates that risk-based intrapartum screening and antibiotics have reduced the incidence of EOD, but not LOD, in Denmark. No clinical or laboratory tests can rule out GBS disease at symptom onset. Thus, a high proportion of uninfected infants receive antibiotics, although this varies widely, and may be reduced by strategies of antibiotic stewardship. A future GBS vaccine for pregnant women may potentially reduce disease burden and antibiotic exposure.

AB - Group B Streptococcus (GBS) disease in neonates occurs in two forms: early-onset disease (EOD), (day 0-6), and late-onset disease (LOD), (day 7-90). This review investigates that risk-based intrapartum screening and antibiotics have reduced the incidence of EOD, but not LOD, in Denmark. No clinical or laboratory tests can rule out GBS disease at symptom onset. Thus, a high proportion of uninfected infants receive antibiotics, although this varies widely, and may be reduced by strategies of antibiotic stewardship. A future GBS vaccine for pregnant women may potentially reduce disease burden and antibiotic exposure.

KW - Humans

KW - Streptococcal Infections/diagnosis

KW - Infant, Newborn

KW - Streptococcus agalactiae/isolation & purification

KW - Anti-Bacterial Agents/therapeutic use

KW - Female

KW - Pregnancy

KW - Denmark/epidemiology

KW - Pregnancy Complications, Infectious/diagnosis

KW - Infant

KW - Streptococcal Vaccines/administration & dosage

KW - Infectious Disease Transmission, Vertical/prevention & control

UR - https://ugeskriftet.dk/videnskab/gruppe-b-streptokokker-hos-nyfoedte-og-i-de-foerste-tre-levemaaneder

UR - https://www.scopus.com/pages/publications/85197706909

U2 - 10.61409/V01240022

DO - 10.61409/V01240022

M3 - Review

C2 - 38953689

SN - 0041-5782

VL - 186

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 26

M1 - V01240022

ER -

Gruppe B-streptokokker hos nyfødte og i de første tre levemåneder

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