Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Growth of the thoracic aorta in the smoking population: The Danish Lung Cancer Screening Trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prolonged QT-interval in cirrhosis: is it reversible?

    Research output: Contribution to journalEditorialpeer-review

  2. Electrocardiographic T-wave morphology and risk of mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Association between the E-wave propagation index and left ventricular thrombus formation after ST-elevation myocardial infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Right atrial strain: Tapping into a new reservoir of hemodynamic information

    Research output: Contribution to journalEditorialpeer-review

  1. Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Danish comorbidity in liver transplant recipients study (DACOLT): a non-interventional prospective observational cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prognostic Value of Coronary CT Angiography in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Clinical pre-test probability for obstructive coronary artery disease: insights from the European DISCHARGE pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Left ventricular myocardial crypts: morphological patterns and prognostic implications

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Lidia R Bons
  • Zahra Sedghi Gamechi
  • Carlijn G E Thijssen
  • Klaus F Kofoed
  • Jesper H Pedersen
  • Zaigham Saghir
  • Johanna J M Takkenberg
  • Isabella Kardys
  • Ricardo P J Budde
  • Marleen de Bruijne
  • Jolien W Roos-Hesselink
View graph of relations

BACKGROUND: Although the descending aortic diameter is larger in smokers, data about thoracic aortic growth is missing. Our aim is to present the distribution of thoracic aortic growth in smokers and to compare it with literature of the general population.

METHODS: Current and ex-smokers aged 50-70 years from the longitudinal Danish Lung Cancer Screening Trial, were included. Mean and 95th percentile of annual aortic growth of the ascending aortic (AA) and descending aortic (DA) diameters were calculated with the first and last non-contrast computed tomography scans during follow-up. Determinants of change in aortic diameter over time were investigated with linear mixed models.

RESULTS: A total of 1987 participants (56% male, mean age 57.4 ± 4.8 years) were included. During a median follow-up of 48 months, mean AA and DA growth rates were comparable between males (AA 0.12 ± 0.31 mm/year and DA 0.10 ± 0.30 mm/year) and females (AA 0.11 ± 0.29 mm/year and DA 0.13 ± 0.27 mm/year). The 95th percentile ranged from 0.42 to 0.47 mm/year, depending on sex and location. Aortic growth was comparable between current and ex-smokers and aortic growth was not associated with pack-years. Our findings are consistent with aortic growth rates of 0.08 to 0.17 mm/years in the general population. Larger aortic growth was associated with lower age, increased height, absence of medication for hypertension or hypercholesterolemia and lower Agatston scores.

CONCLUSIONS: This longitudinal study of smokers in the age range of 50-70 years shows that ascending and descending aortic growth is approximately 0.1 mm/year and is consistent with growth in the general population.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume299
Pages (from-to)276-281
Number of pages6
ISSN0167-5273
DOIs
Publication statusPublished - 15 Jan 2020

    Research areas

  • Aftercare/statistics & numerical data, Aorta, Thoracic/diagnostic imaging, Data Interpretation, Statistical, Denmark, Early Detection of Cancer/methods, Ex-Smokers/statistics & numerical data, Female, Humans, Lung Neoplasms/diagnosis, Male, Middle Aged, Multidetector Computed Tomography/methods, Netherlands, Organ Size, Radiography, Thoracic/methods, Smokers/statistics & numerical data, Smoking/epidemiology

ID: 61845966