Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Growth hormone (GH) hypersecretion and GH receptor resistance in streptozotocin diabetic mice in response to a GH secretagogue

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Cell-Free Fetal DNA in the Early and Late First Trimester

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Endokrinologi

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  3. Diabetes i familien – familien og diabetes

    Research output: Contribution to journalContribution to newspaper - Comment/debateCommunication

View graph of relations

The growth hormone (GH) and insulin-like growth factor I (IGF-I) axis were studied in streptozotocin (STZ) diabetic and nondiabetic female mice following intravenous (IV) injection of the GH secretagogue (GHS) ipamorelin or saline. On day 14, blood samples were obtained before and 10 minutes after the injection. Livers were removed and frozen for determination of the mRNA expressions of the GH receptor, GH-binding protein, and IGF-I, and hepatic IGF-I peptide. Serum samples were analyzed for GH and IGF-I. Following ipamorelin injection, the GH levels were found to be 150 +/- 35 microg/L and 62 +/- 11 microg/L in the diabetic compared to the nondiabetic mice (P <.05). Serum IGF-I levels were lower in diabetic than in nondiabetic animals, and rose after stimulation only in the nondiabetic animals. Furthermore, hepatic GH resistance and IGF-I mRNA levels and IGF-I peptide were increased in nondiabetic animals in response to GH stimulation, whereas the low levels per se of all these parameters in diabetic mice were unaffected. The study shows that STZ diabetic mice demonstrate a substantial part of the clinical features of type 1 diabetes in humans, including GH hypersecretion and GH resistance. Accordingly, it is proposed that STZ diabetic mice may be a better model of the perturbations of the GH/IGF-I axis in diabetes than STZ diabetic rats.

Original languageEnglish
JournalExperimental Diabesity Research
Issue number2
Pages (from-to)73-81
Number of pages9
Publication statusPublished - 25 Nov 2003
Externally publishedYes

    Research areas

  • Animals, Diabetes Mellitus, Experimental, Disease Models, Animal, Female, Growth Hormone, Humans, Insulin-Like Growth Factor I, Liver, Mice, Mice, Inbred BALB C, Oligopeptides, Rats, Receptors, Somatotropin, Reference Values, Journal Article, Research Support, Non-U.S. Gov't

ID: 51976937