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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

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OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.

METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.

RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

Original languageEnglish
JournalMitochondrion
Volume50
Pages (from-to)35-41
Number of pages7
ISSN1567-7249
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • Exercise, Growth and differentiation factor 15, Metabolic myopathy, Mitochondrial myopathy, Muscular dystrophy

ID: 58350438