Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

Nanna Scharff Poulsen; Karen Lindhardt Madsen; Tessa Munkeboe Hornsyld; Anne-Sofie Vibæk Eisum; Freja Fornander; Astrid Emilie Buch; Mads Godtfeldt Stemmerik; Cristina Ruiz-Ruiz; Thomas Oliver Krag; John Vissing

doi:10.1016/j.mito.2019.10.005

Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

Nanna Scharff Poulsen, Karen Lindhardt Madsen, Tessa Munkeboe Hornsyld, Anne-Sofie Vibæk Eisum, Freja Fornander, Astrid Emilie Buch, Mads Godtfeldt Stemmerik, Cristina Ruiz-Ruiz, Thomas Oliver Krag, John Vissing

Department of Neurology

37 Citations (Scopus)

Abstract

OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.

METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.

RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

Original language	English
Journal	Mitochondrion
Volume	50
Pages (from-to)	35-41
Number of pages	7
ISSN	1567-7249
DOIs	https://doi.org/10.1016/j.mito.2019.10.005
Publication status	Published - Jan 2020

Keywords

Exercise
Growth and differentiation factor 15
Metabolic myopathy
Mitochondrial myopathy
Muscular dystrophy

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10.1016/j.mito.2019.10.005

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title = "Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy",

abstract = "OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.",

keywords = "Exercise, Growth and differentiation factor 15, Metabolic myopathy, Mitochondrial myopathy, Muscular dystrophy",

author = "Poulsen, {Nanna Scharff} and Madsen, {Karen Lindhardt} and Hornsyld, {Tessa Munkeboe} and Eisum, {Anne-Sofie Vib{\ae}k} and Freja Fornander and Buch, {Astrid Emilie} and Stemmerik, {Mads Godtfeldt} and Cristina Ruiz-Ruiz and Krag, {Thomas Oliver} and John Vissing",

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doi = "10.1016/j.mito.2019.10.005",

language = "English",

volume = "50",

pages = "35--41",

journal = "Mitochondrion",

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TY - JOUR

T1 - Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

AU - Poulsen, Nanna Scharff

AU - Madsen, Karen Lindhardt

AU - Hornsyld, Tessa Munkeboe

AU - Eisum, Anne-Sofie Vibæk

AU - Fornander, Freja

AU - Buch, Astrid Emilie

AU - Stemmerik, Mads Godtfeldt

AU - Ruiz-Ruiz, Cristina

AU - Krag, Thomas Oliver

AU - Vissing, John

PY - 2020/1

Y1 - 2020/1

N2 - OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

AB - OBJECTIVE: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.METHODS: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.RESULTS AND CONCLUSIONS: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.

KW - Exercise

KW - Growth and differentiation factor 15

KW - Metabolic myopathy

KW - Mitochondrial myopathy

KW - Muscular dystrophy

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U2 - 10.1016/j.mito.2019.10.005

DO - 10.1016/j.mito.2019.10.005

M3 - Journal article

C2 - 31669236

SN - 1567-7249

VL - 50

SP - 35

EP - 41

JO - Mitochondrion

JF - Mitochondrion

ER -

Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

Abstract

Keywords

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