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Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

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Harvard

Lindgren, I, Nenonen, H, Henic, E, Bungum, L, Prahl, A, Bungum, M, Leijonhufvud, I, Huhtaniemi, I, Yding Andersen, C & Lundberg Giwercman, Y 2019, 'Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization', Journal of Assisted Reproduction and Genetics, vol. 36, no. 1, pp. 29-38. https://doi.org/10.1007/s10815-018-1318-y

APA

Lindgren, I., Nenonen, H., Henic, E., Bungum, L., Prahl, A., Bungum, M., Leijonhufvud, I., Huhtaniemi, I., Yding Andersen, C., & Lundberg Giwercman, Y. (2019). Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization. Journal of Assisted Reproduction and Genetics, 36(1), 29-38. https://doi.org/10.1007/s10815-018-1318-y

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MLA

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Author

Lindgren, I. ; Nenonen, H. ; Henic, E. ; Bungum, L. ; Prahl, A. ; Bungum, M. ; Leijonhufvud, I. ; Huhtaniemi, I. ; Yding Andersen, C. ; Lundberg Giwercman, Y. / Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization. In: Journal of Assisted Reproduction and Genetics. 2019 ; Vol. 36, No. 1. pp. 29-38.

Bibtex

@article{a3e5e99e9b9e41d9b258285b5a294d8d,
title = "Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization",
abstract = "Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.",
keywords = "FSH receptor, In vitro fertilization, Infertility, LHCG receptor, Polymorphism, Humans, Live Birth, Treatment Outcome, Receptors, FSH/genetics, Polymorphism, Genetic, Pregnancy, Fertilization in Vitro, Adult, Female, Birth Rate, Receptors, LH/genetics, Pregnancy Rate",
author = "I. Lindgren and H. Nenonen and E. Henic and L. Bungum and A. Prahl and M. Bungum and I. Leijonhufvud and I. Huhtaniemi and {Yding Andersen}, C. and {Lundberg Giwercman}, Y.",
year = "2019",
doi = "10.1007/s10815-018-1318-y",
language = "English",
volume = "36",
pages = "29--38",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York LLC",
number = "1",

}

RIS

TY - JOUR

T1 - Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

AU - Lindgren, I.

AU - Nenonen, H.

AU - Henic, E.

AU - Bungum, L.

AU - Prahl, A.

AU - Bungum, M.

AU - Leijonhufvud, I.

AU - Huhtaniemi, I.

AU - Yding Andersen, C.

AU - Lundberg Giwercman, Y.

PY - 2019

Y1 - 2019

N2 - Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.

AB - Purpose: The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). Methods: A total of 665 women were consecutively enrolled for IVF during the period 2007–2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21–35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Results: Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Conclusions: Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.

KW - FSH receptor

KW - In vitro fertilization

KW - Infertility

KW - LHCG receptor

KW - Polymorphism

KW - Humans

KW - Live Birth

KW - Treatment Outcome

KW - Receptors, FSH/genetics

KW - Polymorphism, Genetic

KW - Pregnancy

KW - Fertilization in Vitro

KW - Adult

KW - Female

KW - Birth Rate

KW - Receptors, LH/genetics

KW - Pregnancy Rate

UR - http://www.scopus.com/inward/record.url?scp=85053533561&partnerID=8YFLogxK

U2 - 10.1007/s10815-018-1318-y

DO - 10.1007/s10815-018-1318-y

M3 - Journal article

C2 - 30232643

AN - SCOPUS:85053533561

VL - 36

SP - 29

EP - 38

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 1

ER -

ID: 55361055