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Glutathione treatment of hepatocellular carcinoma

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  1. The effect of insulin and glucagon on splanchnic oxygen consumption

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  2. Artificial and bioartificial support systems for liver failure: a Cochrane Hepato-Biliary Group Protocol

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  3. Meta-analysis of propylthiouracil for alcoholic liver disease--a Cochrane Hepato-Biliary Group Review

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  4. Chinese medicinal herbs for chronic hepatitis B: a systematic review

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  5. Colchicine for alcoholic and non-alcoholic liver fibrosis or cirrhosis

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This prospective study was undertaken to substantiate observations that glutathione (GSH) inhibits or reverses tumor growth in humans with hepatocellular carcinoma (HCC), a neoplasm with an extremely poor prognosis. Eight patients with biopsy-proven HCC not amenable to surgery were given 5 g of GSH daily from the time of diagnosis. Two patients withdrew shortly after receiving GSH due to intolerable side-effects. Of the six eligible patients, two had mildly advanced tumors and four moderately advanced tumors. At 1-2-month intervals the liver was CT and ultra-sound scanned to assess the growth status of the tumor (progression, stagnation or regression). All the patients, except a male with a fibrolamellar type of HCC, died within 1 year after diagnosis. Two women with moderately advanced tumors survived almost 1 year, tumor growth stopped or regressed and in one of the women an initially abnormal alfa-1-fetoprotein (AFP) returned to normal after GSH treatment. AFP remained normal throughout the treatment period in the other women. These observations indicate that GSH may have a sex-dependent effect on HCC. However, further studies involving more patients are required to pursue this hypothesis.

Original languageEnglish
JournalLiver
Volume12
Issue number5
Pages (from-to)341-3
Number of pages3
ISSN0106-9543
Publication statusPublished - Oct 1992

    Research areas

  • Adult, Carcinoma, Hepatocellular, Female, Glutathione, Humans, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Sex Factors, Survival Rate, Tomography, X-Ray Computed, Ultrasonography, alpha-Fetoproteins, Journal Article

ID: 49583691