Glucose production during exercise in humans: a-hv balance and isotopic-tracer measurements compared

R Bergeron, M Kjaer, L Simonsen, J Bülow, H Galbo

21 Citations (Scopus)


The present study compared the arteriohepatic venous (a-hv) balance technique and the tracer-dilution method for estimation of hepatic glucose production during both moderate and heavy exercise in humans. Eight healthy young men (aged 25 yr; range, 23-30 yr) performed semisupine cycling for 40 min at 50.4 +/- 1.5(SE)% maximal O(2) consumption, followed by 30 min at 69.0 +/- 2.2% maximal O(2) consumption. The splanchnic blood flow was estimated by continuous infusion of indocyanine green, and net splanchnic glucose output was calculated as the product of splanchnic blood flow and a-hv blood glucose concentration differences. Glucose appearance rate was determined by a primed, continuous infusion of [3-(3)H]glucose and was calculated by using formulas for a modified single compartment in non-steady state. Glucose production was similar whether determined by the a-hv balance technique or by the tracer-dilution method, both at rest and during moderate and intense exercise (P > 0. 05). It is concluded that, during exercise in humans, determination of hepatic glucose production can be performed equally well with the two techniques.
Original languageEnglish
JournalJournal of Applied Physiology
Issue number1
Pages (from-to)111-5
Number of pages5
Publication statusPublished - Jul 1999


  • Adult
  • Coloring Agents
  • Evaluation Studies as Topic
  • Exercise
  • Glucose
  • Humans
  • Indocyanine Green
  • Liver
  • Male
  • Oxygen Consumption
  • Splanchnic Circulation
  • Tritium


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