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Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

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Vegge, A, Thymann, T, Lund, P, Stoll, B, Bering, SB, Hartmann, B, Jelsing, J, Qvist, N, Burrin, DG, Jeppesen, PB, Holst, JJ & Sangild, PT 2013, 'Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates' American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 305, no. 4, pp. G277-85. https://doi.org/10.1152/ajpgi.00064.2013

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Author

Vegge, Andreas ; Thymann, Thomas ; Lund, Pernille ; Stoll, Barbara ; Bering, Stine Brandt ; Hartmann, Bolette ; Jelsing, Jacob ; Qvist, Niels ; Burrin, Douglas G ; Jeppesen, Palle B ; Holst, Jens Juul ; Sangild, Per Torp. / Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2013 ; Vol. 305, No. 4. pp. G277-85.

Bibtex

@article{699b3065d8c94afbac3c98b34d3f173a,
title = "Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates",
abstract = "Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50{\%} of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22{\%}), energy (79 vs. 64{\%}), and all macronutrients (all parameters P",
keywords = "Adaptation, Physiological, Animal Nutritional Physiological Phenomena, Animals, Animals, Newborn, Cell Proliferation, DNA Replication, Disease Models, Animal, Enteral Nutrition, Gestational Age, Glucagon-Like Peptide 2, Humans, Intestinal Absorption, Intestine, Small, Jejunostomy, Nutritional Status, Parenteral Nutrition, Total, Premature Birth, Protein Biosynthesis, Recombinant Proteins, Short Bowel Syndrome, Sucrase, Swine, Time Factors, Weight Gain, alpha-Glucosidases",
author = "Andreas Vegge and Thomas Thymann and Pernille Lund and Barbara Stoll and Bering, {Stine Brandt} and Bolette Hartmann and Jacob Jelsing and Niels Qvist and Burrin, {Douglas G} and Jeppesen, {Palle B} and Holst, {Jens Juul} and Sangild, {Per Torp}",
year = "2013",
month = "8",
day = "15",
doi = "10.1152/ajpgi.00064.2013",
language = "English",
volume = "305",
pages = "G277--85",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

AU - Vegge, Andreas

AU - Thymann, Thomas

AU - Lund, Pernille

AU - Stoll, Barbara

AU - Bering, Stine Brandt

AU - Hartmann, Bolette

AU - Jelsing, Jacob

AU - Qvist, Niels

AU - Burrin, Douglas G

AU - Jeppesen, Palle B

AU - Holst, Jens Juul

AU - Sangild, Per Torp

PY - 2013/8/15

Y1 - 2013/8/15

N2 - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P

AB - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P

KW - Adaptation, Physiological

KW - Animal Nutritional Physiological Phenomena

KW - Animals

KW - Animals, Newborn

KW - Cell Proliferation

KW - DNA Replication

KW - Disease Models, Animal

KW - Enteral Nutrition

KW - Gestational Age

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Intestinal Absorption

KW - Intestine, Small

KW - Jejunostomy

KW - Nutritional Status

KW - Parenteral Nutrition, Total

KW - Premature Birth

KW - Protein Biosynthesis

KW - Recombinant Proteins

KW - Short Bowel Syndrome

KW - Sucrase

KW - Swine

KW - Time Factors

KW - Weight Gain

KW - alpha-Glucosidases

U2 - 10.1152/ajpgi.00064.2013

DO - 10.1152/ajpgi.00064.2013

M3 - Journal article

VL - 305

SP - G277-85

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 4

ER -

ID: 42486632