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Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

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  • Andreas Vegge
  • Thomas Thymann
  • Pernille Lund
  • Barbara Stoll
  • Stine Brandt Bering
  • Bolette Hartmann
  • Jacob Jelsing
  • Niels Qvist
  • Douglas G Burrin
  • Palle B Jeppesen
  • Jens Juul Holst
  • Per Torp Sangild
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Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P
Original languageEnglish
JournalAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Volume305
Issue number4
Pages (from-to)G277-85
ISSN0193-1857
DOIs
Publication statusPublished - 15 Aug 2013

    Research areas

  • Adaptation, Physiological, Animal Nutritional Physiological Phenomena, Animals, Animals, Newborn, Cell Proliferation, DNA Replication, Disease Models, Animal, Enteral Nutrition, Gestational Age, Glucagon-Like Peptide 2, Humans, Intestinal Absorption, Intestine, Small, Jejunostomy, Nutritional Status, Parenteral Nutrition, Total, Premature Birth, Protein Biosynthesis, Recombinant Proteins, Short Bowel Syndrome, Sucrase, Swine, Time Factors, Weight Gain, alpha-Glucosidases

ID: 42486632