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Glucagon Receptor Signaling and Glucagon Resistance

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  1. Methods and guidelines for measurement of glucagon in plasma

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  2. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

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  3. The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion - A Review

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  4. Evolution and Medical Significance of LU Domain-Containing Proteins

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  1. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

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  2. The Effect of Different Training Intensities on Oxidatively Generated Modifications of Nucleic Acids: A Randomized, Controlled Trial

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  3. Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

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  4. Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon

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Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas). The suggested key role of glucagon in the development of diabetes has been termed the bihormonal hypothesis. However, studying tissue-specific knockout of the glucagon receptor has revealed that the physiological role of glucagon may extend beyond blood-glucose regulation. Decades ago, animal and human studies reported an important role of glucagon in amino acid metabolism through ureagenesis. Using modern technologies such as metabolomic profiling, knowledge about the effects of glucagon on amino acid metabolism has been expanded and the mechanisms involved further delineated. Glucagon receptor antagonists have indirectly put focus on glucagon's potential role in lipid metabolism, as individuals treated with these antagonists showed dyslipidemia and increased hepatic fat. One emerging field in glucagon biology now seems to include the concept of hepatic glucagon resistance. Here, we discuss the roles of glucagon in glucose homeostasis, amino acid metabolism, and lipid metabolism and present speculations on the molecular pathways causing and associating with postulated hepatic glucagon resistance.

Original languageEnglish
Article number3314
JournalInternational Journal of Molecular Sciences
Volume20
Issue number13
ISSN1661-6596
DOIs
Publication statusPublished - 5 Jul 2019

    Research areas

  • Alpha cell, Alpha cell axis, Amino acids, Diabetes, Glucose, Hyperaminoacidemia, Hyperglucagonemia, Liver

ID: 57538051