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Glucagon Receptor Signaling and Glucagon Resistance

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DOI

  1. The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review

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  2. Evolution and Medical Significance of LU Domain-Containing Proteins

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  3. Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training

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  4. 5hmC Level Predicts Biochemical Failure Following Radical Prostatectomy in Prostate Cancer Patients with ERG Negative Tumors

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  1. Greater glucagon-like peptide-1 responses to oral glucose are associated with lower central and peripheral blood pressures

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  2. The Liver-α-Cell Axis and Type 2 Diabetes

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  3. Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes

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  4. Gut-derived glucagon in man

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Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas). The suggested key role of glucagon in the development of diabetes has been termed the bihormonal hypothesis. However, studying tissue-specific knockout of the glucagon receptor has revealed that the physiological role of glucagon may extend beyond blood-glucose regulation. Decades ago, animal and human studies reported an important role of glucagon in amino acid metabolism through ureagenesis. Using modern technologies such as metabolomic profiling, knowledge about the effects of glucagon on amino acid metabolism has been expanded and the mechanisms involved further delineated. Glucagon receptor antagonists have indirectly put focus on glucagon's potential role in lipid metabolism, as individuals treated with these antagonists showed dyslipidemia and increased hepatic fat. One emerging field in glucagon biology now seems to include the concept of hepatic glucagon resistance. Here, we discuss the roles of glucagon in glucose homeostasis, amino acid metabolism, and lipid metabolism and present speculations on the molecular pathways causing and associating with postulated hepatic glucagon resistance.

Original languageEnglish
Article number3314
JournalInternational Journal of Molecular Sciences
Volume20
Issue number13
Pages (from-to)3314
ISSN1661-6596
DOIs
Publication statusPublished - 5 Jul 2019

    Research areas

  • Alpha cell, Alpha cell axis, Amino acids, Diabetes, Glucose, Hyperaminoacidemia, Hyperglucagonemia, Liver

ID: 57538051