TY - JOUR
T1 - Global Prevalence of Young-Onset Dementia
T2 - A Systematic Review and Meta-analysis
AU - Hendriks, Stevie
AU - Peetoom, Kirsten
AU - Bakker, Christian
AU - van der Flier, Wiesje M
AU - Papma, Janne M
AU - Koopmans, Raymond
AU - Verhey, Frans R J
AU - de Vugt, Marjolein
AU - Köhler, Sebastian
AU - Young-Onset Dementia Epidemiology Study Group
AU - De Guzman, Ma Fe
AU - Broe, Tony
AU - Subramaniam, Mythily
AU - Abdin, Edimansyah
AU - Bruni, Amalia C
AU - Di Lorenzo, Raffaele
AU - Smith, Kate
AU - Flicker, Leon
AU - Mol, Merel O
AU - Basta, Maria
AU - Yu, Doris
AU - Masika, Golden
AU - Petersen, Maria S
AU - Ruano, Luis
A2 - Withall, Adrienne
A2 - Parlevliet, Juliette L
A2 - Uysal-Bozkir, Özgül
A2 - Gibson, Roger C
A2 - Neita, Susanne M
A2 - Nielsen, Thomas Rune
A2 - Salem, Lise C
A2 - Nyberg, Jenny
A2 - Lopes, Marcos Antonio
A2 - Dominguez, Jacqueline C
A2 - Egeberg, Alexander
A2 - Radford, Kylie
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Importance: Reliable prevalence estimates are lacking for young-onset dementia (YOD), in which symptoms of dementia start before the age of 65 years. Such estimates are needed for policy makers to organize appropriate health care.Objective: To determine the global prevalence of YOD.Data Sources: The PubMed, Embase, CINAHL, and PsycInfo databases were systematically searched for population-based studies on the prevalence of YOD published between January 1, 1990, and March 31, 2020.Study Selection: Studies containing data on the prevalence of dementia in individuals younger than 65 years were screened by 2 researchers for inclusion in a systematic review and meta-analysis.Data Extraction and Synthesis: Prevalence estimates on 5-year age bands, from 30 to 34 years to 60 to 64 years, were extracted. Random-effects meta-analyses were conducted to pool prevalence estimates. Results were age standardized for the World Standard Population. Heterogeneity was assessed by subgroup analyses for sex, dementia subtype, study design, and economic status based on the World Bank classification and by meta-regression.Main Outcomes and Measures: Prevalence estimates of YOD for 5-year age bands.Results: A total of 95 unique studies were included in this systematic review, of which 74 with 2 760 379 unique patients were also included in 5-year age band meta-analyses. Studies were mostly conducted in Europe and in older groups in Asia, North America, and Oceania. Age-standardized prevalence estimates increased from 1.1 per 100 000 population in the group aged 30 to 34 years to 77.4 per 100 000 population in the group aged 60 to 64 years. This gives an overall global age-standardized prevalence of 119.0 per 100 000 population in the age range of 30 to 64 years, corresponding to 3.9 million people aged 30 to 64 years living with YOD in the world. Subgroup analyses showed prevalence between men and women to be similar (crude estimates for men, 216.5 per 100 000 population; for women, 293.1 per 100 000 population), whereas prevalence was lower in high-income countries (crude estimate, 663.9 per 100 000 population) compared with upper-middle-income (crude estimate, 1873.6 per 100 000 population) and lower-middle-income (crude estimate, 764.2 per 100 000 population) countries. Meta-regression showed that age range (P < .001), sample size (P < .001), and study methodology (P = .02) significantly influenced heterogeneity between studies.Conclusions and Relevance: This systematic review and meta-analysis found an age-standardized prevalence of YOD of 119.0 per 100 000 population, although estimates of the prevalence in low-income countries and younger age ranges remain scarce. These results should help policy makers organize sufficient health care for this subgroup of individuals with dementia.Study Registration: PROSPERO CRD42019119288.
AB - Importance: Reliable prevalence estimates are lacking for young-onset dementia (YOD), in which symptoms of dementia start before the age of 65 years. Such estimates are needed for policy makers to organize appropriate health care.Objective: To determine the global prevalence of YOD.Data Sources: The PubMed, Embase, CINAHL, and PsycInfo databases were systematically searched for population-based studies on the prevalence of YOD published between January 1, 1990, and March 31, 2020.Study Selection: Studies containing data on the prevalence of dementia in individuals younger than 65 years were screened by 2 researchers for inclusion in a systematic review and meta-analysis.Data Extraction and Synthesis: Prevalence estimates on 5-year age bands, from 30 to 34 years to 60 to 64 years, were extracted. Random-effects meta-analyses were conducted to pool prevalence estimates. Results were age standardized for the World Standard Population. Heterogeneity was assessed by subgroup analyses for sex, dementia subtype, study design, and economic status based on the World Bank classification and by meta-regression.Main Outcomes and Measures: Prevalence estimates of YOD for 5-year age bands.Results: A total of 95 unique studies were included in this systematic review, of which 74 with 2 760 379 unique patients were also included in 5-year age band meta-analyses. Studies were mostly conducted in Europe and in older groups in Asia, North America, and Oceania. Age-standardized prevalence estimates increased from 1.1 per 100 000 population in the group aged 30 to 34 years to 77.4 per 100 000 population in the group aged 60 to 64 years. This gives an overall global age-standardized prevalence of 119.0 per 100 000 population in the age range of 30 to 64 years, corresponding to 3.9 million people aged 30 to 64 years living with YOD in the world. Subgroup analyses showed prevalence between men and women to be similar (crude estimates for men, 216.5 per 100 000 population; for women, 293.1 per 100 000 population), whereas prevalence was lower in high-income countries (crude estimate, 663.9 per 100 000 population) compared with upper-middle-income (crude estimate, 1873.6 per 100 000 population) and lower-middle-income (crude estimate, 764.2 per 100 000 population) countries. Meta-regression showed that age range (P < .001), sample size (P < .001), and study methodology (P = .02) significantly influenced heterogeneity between studies.Conclusions and Relevance: This systematic review and meta-analysis found an age-standardized prevalence of YOD of 119.0 per 100 000 population, although estimates of the prevalence in low-income countries and younger age ranges remain scarce. These results should help policy makers organize sufficient health care for this subgroup of individuals with dementia.Study Registration: PROSPERO CRD42019119288.
UR - http://www.scopus.com/inward/record.url?scp=85110480879&partnerID=8YFLogxK
U2 - 10.1001/jamaneurol.2021.2161
DO - 10.1001/jamaneurol.2021.2161
M3 - Review
C2 - 34279544
SN - 2168-6149
VL - 78
SP - 1080
EP - 1090
JO - JAMA Neurology
JF - JAMA Neurology
IS - 9
ER -