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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease - A systematic review and meta-analysis

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DOI

  1. Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study

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  2. Quality of care standards in inflammatory bowel diseases: a European Crohn's and Colitis Organisation (ECCO) position paper

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  3. The Sooner the Better? Cost-effectiveness of Early Biological Therapy in Patients With Crohn's Disease

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  4. ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment

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  1. Clinical Relevance of Skin Pain in Atopic Dermatitis

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  2. Impact of Atopic Dermatitis Lesion Location on Quality of Life in Adult Patients in a Real-world Study

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Background and Aims: Epidemiological studies have established an association between psoriasis and inflammatory bowel disease [IBD], i.e. ulcerative colitis [UC] and Crohn's disease [CD], but results are inconsistent. The aim of this study was therefore to quantify the prevalences and association between IBD and psoriasis. Methods: PubMed, Web of Science, and EMBASE were searched from database inception through April 2018 for studies reporting data on psoriasis among patients with IBD and vice versa. Meta-analysis was performed to estimate, respectively, the prevalences and association between IBD and psoriasis. Data extraction was according to the PRISMA guideline, and quality assessment was made using the Newcastle-Ottawa Scale. The main outcomes were the proportion of psoriasis patients with IBD and vice versa, as well as the association (odds ratio [OR]) of IBD in psoriasis and psoriasis in IBD, respectively. Results: Based on quantitative analysis of 93 studies, the prevalence of psoriasis in CD and in UC was 3.6% (95% confidence interval [CI] 3.1%-4.6%) and 2.8% [95% CI 2.0%-3.8%] respectively. The prevalence of CD and UC was 0.7% [95% CI 0.2%-1.3%] and 0.5% [95% CI 0.3%-0.8%], respectively, among patients with psoriasis. Presence of CD or UC was significantly associated with psoriasis, with OR 2.0 [95% CI 1.4-2.9] and OR 1.5 [95% CI 1.2-2.0], respectively. Presence of psoriasis was significantly associated with CD: OR 2.2 [95% CI 1.6-3.1] and with UC: OR 1.6 [95% CI 1.3-2.0]. Conclusions: We found significant bidirectional associations between psoriasis and IBD, warranting increased awareness among clinicians in the diagnostic process, especially in children and adolescents with IBD. Last, this study showed an increased frequency of paradoxical psoriasis in patients treated with biologics.

Original languageEnglish
JournalJournal of Crohn's & colitis
Volume14
Issue number3
Pages (from-to)351-360
Number of pages10
ISSN1873-9946
DOIs
Publication statusPublished - 13 Mar 2020

    Research areas

  • Crohn's disease, Psoriasis, ulcerative colitis

ID: 57934152