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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study

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  1. Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Finerenone Reduces New-Onset Atrial Fibrillation in Patients With Chronic Kidney Disease and Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Natural History and Clinical Characteristics of the First 10 Danish Families With Familial ST-Depression Syndrome

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  4. Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus

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  5. Prognostic Value of Coronary CT Angiography in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

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  • Roth Gregory A.
  • Mensah George A.
  • Johnson Catherine O.
  • Addolorato Giovanni
  • Ammirati Enrico
  • Baddour Larry M.
  • Barengo Noel C.
  • Beaton Andrea Z.
  • Benjamin Emelia J.
  • Benziger Catherine P.
  • Bonny Aime
  • Brauer Michael
  • Brodmann Marianne
  • Cahill Thomas J.
  • Carapetis Jonathan
  • Catapano Alberico L.
  • Chugh Sumeet S.
  • Cooper Leslie T.
  • Coresh Josef
  • Criqui Michael
  • DeCleene Nicole
  • Eagle Kim A.
  • Emmons-Bell Sophia
  • Feigin Valery L.
  • Fernández-Sola Joaquim
  • Fowkes Gerry
  • Gakidou Emmanuela
  • Grundy Scott M.
  • He Feng J.
  • Howard George
  • Hu Frank
  • Inker Lesley
  • Karthikeyan Ganesan
  • Kassebaum Nicholas
  • Koroshetz Walter
  • Lavie Carl
  • Lloyd-Jones Donald
  • Lu Hong S.
  • Mirijello Antonio
  • Temesgen Awoke Misganaw
  • Mokdad Ali
  • Moran Andrew E.
  • Muntner Paul
  • Narula Jagat
  • Neal Bruce
  • Ntsekhe Mpiko
  • Moraes de Oliveira Glaucia
  • Otto Catherine
  • Owolabi Mayowa
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Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

Original languageEnglish
JournalJournal of the American College of Cardiology
Volume76
Issue number25
Pages (from-to)2982-3021
ISSN0735-1097
DOIs
Publication statusPublished - 22 Dec 2020
Externally publishedYes

ID: 66267672