TY - JOUR
T1 - Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
T2 - Update From the GBD 2019 Study
AU - A., Roth Gregory
AU - A., Mensah George
AU - O., Johnson Catherine
AU - Giovanni, Addolorato
AU - Enrico, Ammirati
AU - M., Baddour Larry
AU - C., Barengo Noel
AU - Z., Beaton Andrea
AU - J., Benjamin Emelia
AU - P., Benziger Catherine
AU - Aime, Bonny
AU - Michael, Brauer
AU - Marianne, Brodmann
AU - J., Cahill Thomas
AU - Jonathan, Carapetis
AU - L., Catapano Alberico
AU - S., Chugh Sumeet
AU - T., Cooper Leslie
AU - Josef, Coresh
AU - Michael, Criqui
AU - Nicole, DeCleene
AU - A., Eagle Kim
AU - Sophia, Emmons-Bell
AU - L., Feigin Valery
AU - Joaquim, Fernández-Sola
AU - Gerry, Fowkes
AU - Emmanuela, Gakidou
AU - M., Grundy Scott
AU - J., He Feng
AU - George, Howard
AU - Frank, Hu
AU - Lesley, Inker
AU - Ganesan, Karthikeyan
AU - Nicholas, Kassebaum
AU - Walter, Koroshetz
AU - Carl, Lavie
AU - Donald, Lloyd-Jones
AU - S., Lu Hong
AU - Antonio, Mirijello
AU - Misganaw, Temesgen Awoke
AU - Ali, Mokdad
AU - E., Moran Andrew
AU - Paul, Muntner
AU - Jagat, Narula
AU - Bruce, Neal
AU - Mpiko, Ntsekhe
AU - Glaucia, Moraes de Oliveira
AU - Catherine, Otto
AU - Mayowa, Owolabi
A2 - Shamali, Mahdi
PY - 2020/12/22
Y1 - 2020/12/22
N2 - Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.
AB - Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.
UR - https://www.scopus.com/pages/publications/85098835749
U2 - 10.1016/j.jacc.2020.11.010
DO - 10.1016/j.jacc.2020.11.010
M3 - Journal article
C2 - 33309175
SN - 0735-1097
VL - 76
SP - 2982
EP - 3021
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 25
ER -