Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. High-intensity training in patients with spinal and bulbar muscular atrophy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Congenital myopathies are mainly associated with a mild cardiac phenotype

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Relationship between muscle inflammation and fat replacement assessed by MRI in facioscapulohumeral muscular dystrophy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Treatment escalation leads to fewer relapses compared with switching to another moderately effective therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Guillain-Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Depressive symptoms and mental health-related quality of life in adolescence and young adulthood after early parental death

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Community-based football in men with prostate cancer: 1-year follow-up on a pragmatic, multicentre randomised controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Educational level and first-time PSA testing in general practice

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Shala G Berntsson
  • Ryan T Merrell
  • E Susan Amirian
  • Georgina N Armstrong
  • Daniel Lachance
  • Anja Smits
  • Renke Zhou
  • Daniel I Jacobs
  • Margaret R Wrensch
  • Sara H Olson
  • Dora Il'yasova
  • Elizabeth B Claus
  • Jill S Barnholtz-Sloan
  • Joellen Schildkraut
  • Siegal Sadetzki
  • Christoffer Johansen
  • Richard S Houlston
  • Robert B Jenkins
  • Jonine L Bernstein
  • Rose Lai
  • Sanjay Shete
  • Christopher I Amos
  • Melissa L Bondy
  • Beatrice S Melin
View graph of relations

BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls.

METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures.

RESULTS: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood.

CONCLUSIONS: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

Original languageEnglish
JournalJournal of Neurology
Volume265
Issue number6
Pages (from-to)1432-1442
Number of pages11
ISSN0340-5354
DOIs
Publication statusPublished - Jun 2018

ID: 54657726