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GH-replacement therapy in adults

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Harvard

Christiansen, JS, Jørgensen, JO, Pedersen, SA, Müller, J, Jørgensen, J, Møller, J, Heickendorf, L & Skakkebaek, NE 1991, 'GH-replacement therapy in adults' Hormone Research, vol. 36 Suppl 1, pp. 66-72.

APA

Christiansen, J. S., Jørgensen, J. O., Pedersen, S. A., Müller, J., Jørgensen, J., Møller, J., ... Skakkebaek, N. E. (1991). GH-replacement therapy in adults. Hormone Research, 36 Suppl 1, 66-72.

CBE

Christiansen JS, Jørgensen JO, Pedersen SA, Müller J, Jørgensen J, Møller J, Heickendorf L, Skakkebaek NE. 1991. GH-replacement therapy in adults. Hormone Research. 36 Suppl 1:66-72.

MLA

Christiansen, J S et al. "GH-replacement therapy in adults". Hormone Research. 1991, 36 Suppl 1. 66-72.

Vancouver

Christiansen JS, Jørgensen JO, Pedersen SA, Müller J, Jørgensen J, Møller J et al. GH-replacement therapy in adults. Hormone Research. 1991;36 Suppl 1:66-72.

Author

Christiansen, J S ; Jørgensen, J O ; Pedersen, S A ; Müller, J ; Jørgensen, J ; Møller, J ; Heickendorf, L ; Skakkebaek, N E. / GH-replacement therapy in adults. In: Hormone Research. 1991 ; Vol. 36 Suppl 1. pp. 66-72.

Bibtex

@article{d5ab9eb0e30641ce9b3fa09160338913,
title = "GH-replacement therapy in adults",
abstract = "Growth hormone (GH) deficiency in adults, whether GH deficient since childhood or patients rendered GH deficient in adult life, is associated with psychosocial maladjustment, reduced muscle strength and reduced exercise capacity. Body composition is significantly altered with increased fat and decreased muscle volume as compared to healthy subjects. Kidney function is subnormal, and so is sweat secretion. Epidemiological data suggest premature mortality due to cardiovascular disease in hypopituitary patients. Short-term GH treatment trials have shown improved psychosocial performance, normalization of body composition, increased muscle strength, improved exercise capacity, increased cardiac performance and increase in bone mineral mass as well as in serum markers of bone turnover, and normalization of kidney function. Thus GH replacement therapy in GH-deficient adults exhibits potential long-term beneficial effects. A number of important questions has to be addressed before long-term GH replacement therapy in GH-deficient adults can be considered on a routine basis.",
keywords = "Adult, Body Composition, Growth Hormone, Heart, Humans, Hypopituitarism, Muscles, Physical Exertion",
author = "Christiansen, {J S} and J{\o}rgensen, {J O} and Pedersen, {S A} and J M{\"u}ller and J J{\o}rgensen and J M{\o}ller and L Heickendorf and Skakkebaek, {N E}",
year = "1991",
language = "English",
volume = "36 Suppl 1",
pages = "66--72",
journal = "Hormone Research",
issn = "0301-0163",
publisher = "S./Karger AG",

}

RIS

TY - JOUR

T1 - GH-replacement therapy in adults

AU - Christiansen, J S

AU - Jørgensen, J O

AU - Pedersen, S A

AU - Müller, J

AU - Jørgensen, J

AU - Møller, J

AU - Heickendorf, L

AU - Skakkebaek, N E

PY - 1991

Y1 - 1991

N2 - Growth hormone (GH) deficiency in adults, whether GH deficient since childhood or patients rendered GH deficient in adult life, is associated with psychosocial maladjustment, reduced muscle strength and reduced exercise capacity. Body composition is significantly altered with increased fat and decreased muscle volume as compared to healthy subjects. Kidney function is subnormal, and so is sweat secretion. Epidemiological data suggest premature mortality due to cardiovascular disease in hypopituitary patients. Short-term GH treatment trials have shown improved psychosocial performance, normalization of body composition, increased muscle strength, improved exercise capacity, increased cardiac performance and increase in bone mineral mass as well as in serum markers of bone turnover, and normalization of kidney function. Thus GH replacement therapy in GH-deficient adults exhibits potential long-term beneficial effects. A number of important questions has to be addressed before long-term GH replacement therapy in GH-deficient adults can be considered on a routine basis.

AB - Growth hormone (GH) deficiency in adults, whether GH deficient since childhood or patients rendered GH deficient in adult life, is associated with psychosocial maladjustment, reduced muscle strength and reduced exercise capacity. Body composition is significantly altered with increased fat and decreased muscle volume as compared to healthy subjects. Kidney function is subnormal, and so is sweat secretion. Epidemiological data suggest premature mortality due to cardiovascular disease in hypopituitary patients. Short-term GH treatment trials have shown improved psychosocial performance, normalization of body composition, increased muscle strength, improved exercise capacity, increased cardiac performance and increase in bone mineral mass as well as in serum markers of bone turnover, and normalization of kidney function. Thus GH replacement therapy in GH-deficient adults exhibits potential long-term beneficial effects. A number of important questions has to be addressed before long-term GH replacement therapy in GH-deficient adults can be considered on a routine basis.

KW - Adult

KW - Body Composition

KW - Growth Hormone

KW - Heart

KW - Humans

KW - Hypopituitarism

KW - Muscles

KW - Physical Exertion

M3 - Journal article

VL - 36 Suppl 1

SP - 66

EP - 72

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

ER -

ID: 44937201