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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Getting to grips with endoscopy - Learning endoscopic surgical skills induces bi-hemispheric plasticity of the grasping network

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  1. Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

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  2. A novel approach to localize cortical TMS effects

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  3. Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation

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  4. The structure of the serotonin system: A PET imaging study

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  5. Validation of structural brain connectivity networks: The impact of scanning parameters

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  1. Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Progressive effects of sildenafil on visual processing in rats

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  3. Discrete finger sequences are widely represented in human striatum

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  4. Differential recurrence after laparoscopic incisional hernia repair: importance of a nationwide registry-based mesh surveillance

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Endoscopic surgery requires skilled bimanual use of complex instruments that extend the peri-personal workspace. To delineate brain structures involved in learning such surgical skills, 48 medical students without surgical experience were randomly assigned to five training sessions on a virtual-reality endoscopy simulator or to a non-training group. Brain activity was probed with functional MRI while participants performed endoscopic tasks. Repeated task performance in the scanner was sufficient to enhance task-related activity in left ventral premotor cortex (PMv) and the anterior Intraparietal Sulcus (aIPS). Simulator training induced additional increases in task-related activation in right PMv and aIPS and reduced effective connectivity from left to right PMv. Skill improvement after training scaled with stronger task-related activation of the lateral left primary motor hand area (M1-HAND). The results suggest that a bilateral fronto-parietal grasping network and left M1-HAND are engaged in bimanual learning of tool-based manipulations in an extended peri-personal space.

Original languageEnglish
JournalNeuroImage
Volume189
Pages (from-to)32-44
Number of pages13
ISSN1053-8119
DOIs
Publication statusPublished - 1 Apr 2019

    Research areas

  • Bimanual skill learning, Endoscopic surgery, Fronto-parietal grasping network

ID: 55904432