Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genetic variation at PPP1R3B increases hepatic CT attenuation and interacts with prandial status on plasma glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Martin Andreas Røder
  • PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
View graph of relations

Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

Original languageEnglish
JournalNature Communications
Volume9
Issue number1
Pages (from-to)4616
ISSN2041-1723
DOIs
Publication statusPublished - 5 Nov 2018

ID: 56246202