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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Genterapi til sygdomme i centralnervesystemet

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  1. Selvmordsforebyggende klinikker for børn og unge med fokus på Region Hovedstaden

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  2. Epidemiologi for alkoholrelateret leversygdom

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  3. Skadelige konsekvenser af alkoholindtag blandt unge mennesker

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  4. Pregnancy and depression

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  5. Rygning kan have skadelige effekter selv ved ophør før 30-årsalderen

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  1. Retinal layer segmentation in rodent OCT images: Local intensity profiles & fully convolutional neural networks

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  2. Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

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  3. Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

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In recent years, gene therapy has resurged as a potential treatment for an increasing number of medical diseases including those affecting the central nervous system (CNS), which is discussed in this review. Clinical trials have revealed promising results particularly in gene therapy for Parkinson's disease with upregulation of dopamine synthesis or downregulation of huntingtin synthesis in Huntington's disease. Gene therapy for spinal motor atrophy has received FDA approval this year. The biggest success is seen in ophthalmology, where gene therapy has been FDA/EU-approved for retinitis pigmentosa, sparking further hope of use for other CNS diseases in a near future.

Translated title of the contributionGene therapy for central nervous system disorders
Original languageDanish
JournalUgeskrift for Laeger
Volume182
Issue number3
Pages (from-to)V09190535
ISSN0041-5782
Publication statusPublished - 13 Jan 2020

ID: 61290371