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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Gentagne diploid biparental molae

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This review summarises the knowledge of recurrent diploid biparental hydatidiform mole, which is a rare genetic condition. Pathogenic variants in both alleles of NLRP7 or KHDC3L are associated with maternal imprinting defects and can cause the condition. Women with biallelic inactivation of NLRP7 can achieve a normal pregnancy by oocyte donation, and it is highly likely, that this applies to women with biallelic inactivation of KHDCL3 as well. Identifying the cause of the recurrent moles can prevent that couples waist time and possibly reduce medical expenses related to fertility treatment.

Translated title of the contributionRecurrent diploid biparental mole
Original languageDanish
JournalUgeskrift for Laeger
Volume181
Issue number33
ISSN0041-5782
Publication statusPublished - 12 Aug 2019

ID: 58250707