Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{1c0fa810c5be44d5abb7a0b1c309fcf4,
title = "Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma",
abstract = "The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7{\%} carrying loss-of-function and 5{\%} carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70{\%}; P",
author = "Fazila Asmar and Vasu Punj and Jesper Christensen and Marianne Pedersen and Anja Pedersen and Nielsen, {Anders Brink} and Christoffer Hother and Ulrik Ralfkiaer and Peter Brown and Elisabeth Ralfkiaer and Kristian Helin and Kirsten Gr{\o}nb{\ae}k",
year = "2013",
month = "12",
doi = "10.3324/haematol.2013.088740",
language = "English",
volume = "98",
pages = "1912--20",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Fondazione/Ferrata Storti",
number = "12",

}

RIS

TY - JOUR

T1 - Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

AU - Asmar, Fazila

AU - Punj, Vasu

AU - Christensen, Jesper

AU - Pedersen, Marianne

AU - Pedersen, Anja

AU - Nielsen, Anders Brink

AU - Hother, Christoffer

AU - Ralfkiaer, Ulrik

AU - Brown, Peter

AU - Ralfkiaer, Elisabeth

AU - Helin, Kristian

AU - Grønbæk, Kirsten

PY - 2013/12

Y1 - 2013/12

N2 - The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7% carrying loss-of-function and 5% carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70%; P

AB - The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7% carrying loss-of-function and 5% carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70%; P

U2 - 10.3324/haematol.2013.088740

DO - 10.3324/haematol.2013.088740

M3 - Journal article

VL - 98

SP - 1912

EP - 1920

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 12

ER -

ID: 42219604