Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Duffy-null genotype and risk of infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional Assessment of Variants Associated with Wolfram Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Consortium-based genome-wide meta-analysis for childhood dental caries traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of Dapagliflozin in Patients With Kidney Disease, With and Without Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Tarunveer S Ahluwalia
  • Bram P Prins
  • Mohammadreza Abdollahi
  • Nicola J Armstrong
  • Stella Aslibekyan
  • Lisa Bain
  • Barbara Jefferis
  • Jens Baumert
  • Marian Beekman
  • Yoav Ben-Shlomo
  • Joshua C Bis
  • Braxton D Mitchell
  • Eco de Geus
  • Graciela E Delgado
  • Diana Marek
  • Joel Eriksson
  • Eero Kajantie
  • Stavroula Kanoni
  • John P Kemp
  • Chen Lu
  • Riccardo E Marioni
  • Stela McLachlan
  • Yuri Milaneschi
  • Ilja M Nolte
  • Alexandros M Petrelis
  • Eleonora Porcu
  • Maria Sabater-Lleal
  • Elnaz Naderi
  • Ilkka Seppälä
  • Tina Shah
  • Gaurav Singhal
  • Marie Standl
  • Alexander Teumer
  • Anbupalam Thalamuthu
  • Elisabeth Thiering
  • Stella Trompet
  • Christie M Ballantyne
  • Emelia J Benjamin
  • Juan P Casas
  • Catherine Toben
  • George Dedoussis
  • Joris Deelen
  • Peter Durda
  • Jorgen Engmann
  • Mary F Feitosa
  • Harald Grallert
  • Ann Hammarstedt
  • Tine Jess
  • Peter Rossing
  • Thorkild I A Sørensen
  • CHARGE Inflammation Working Group
View graph of relations

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery, and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed-effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on Chromosome (Chr) 2q14, (pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.

Original languageEnglish
JournalHuman Molecular Genetics
Volume30
Issue number5
Pages (from-to)393-409
Number of pages17
ISSN0964-6906
DOIs
Publication statusPublished - Mar 2021

ID: 64864233