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Genome-wide association analysis identifies a meningioma risk locus at 11p15.5

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Claus, EB, Cornish, AJ, Broderick, P, Schildkraut, JM, Dobbins, SE, Holroyd, A, Calvocoressi, L, Lu, L, Hansen, HM, Smirnov, I, Walsh, KM, Schramm, J, Hoffmann, P, Nöthen, MM, Jöckel, K-H, Swerdlow, A, Larsen, SB, Johansen, C, Simon, M, Bondy, M, Wrensch, M, Houlston, R & Wiemels, JL 2018, 'Genome-wide association analysis identifies a meningioma risk locus at 11p15.5', Neuro-Oncology, vol. 20, no. 11, pp. 1485-1493. https://doi.org/10.1093/neuonc/noy077

APA

Claus, E. B., Cornish, A. J., Broderick, P., Schildkraut, J. M., Dobbins, S. E., Holroyd, A., Calvocoressi, L., Lu, L., Hansen, H. M., Smirnov, I., Walsh, K. M., Schramm, J., Hoffmann, P., Nöthen, M. M., Jöckel, K-H., Swerdlow, A., Larsen, S. B., Johansen, C., Simon, M., ... Wiemels, J. L. (2018). Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology, 20(11), 1485-1493. https://doi.org/10.1093/neuonc/noy077

CBE

Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel K-H, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston R, Wiemels JL. 2018. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology. 20(11):1485-1493. https://doi.org/10.1093/neuonc/noy077

MLA

Vancouver

Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A et al. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology. 2018;20(11):1485-1493. https://doi.org/10.1093/neuonc/noy077

Author

Claus, Elizabeth B ; Cornish, Alex J ; Broderick, Peter ; Schildkraut, Joellen M ; Dobbins, Sara E ; Holroyd, Amy ; Calvocoressi, Lisa ; Lu, Lingeng ; Hansen, Helen M ; Smirnov, Ivan ; Walsh, Kyle M ; Schramm, Johannes ; Hoffmann, Per ; Nöthen, Markus M ; Jöckel, Karl-Heinz ; Swerdlow, Anthony ; Larsen, Signe Benzon ; Johansen, Christoffer ; Simon, Matthias ; Bondy, Melissa ; Wrensch, Margaret ; Houlston, Richard ; Wiemels, Joseph L. / Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. In: Neuro-Oncology. 2018 ; Vol. 20, No. 11. pp. 1485-1493.

Bibtex

@article{7429f6bf42f04a5abab3c828664fabf8,
title = "Genome-wide association analysis identifies a meningioma risk locus at 11p15.5",
abstract = "BACKGROUND: Meningioma are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of two GWAS, imputed using a merged reference panel of 1,000 Genomes and UK10K data, with validation in two independent sample series totaling 2,138 cases and 12,081 controls.RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.",
author = "Claus, {Elizabeth B} and Cornish, {Alex J} and Peter Broderick and Schildkraut, {Joellen M} and Dobbins, {Sara E} and Amy Holroyd and Lisa Calvocoressi and Lingeng Lu and Hansen, {Helen M} and Ivan Smirnov and Walsh, {Kyle M} and Johannes Schramm and Per Hoffmann and N{\"o}then, {Markus M} and Karl-Heinz J{\"o}ckel and Anthony Swerdlow and Larsen, {Signe Benzon} and Christoffer Johansen and Matthias Simon and Melissa Bondy and Margaret Wrensch and Richard Houlston and Wiemels, {Joseph L}",
year = "2018",
doi = "10.1093/neuonc/noy077",
language = "English",
volume = "20",
pages = "1485--1493",
journal = "Neuro-Oncology",
issn = "1522-8517",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Genome-wide association analysis identifies a meningioma risk locus at 11p15.5

AU - Claus, Elizabeth B

AU - Cornish, Alex J

AU - Broderick, Peter

AU - Schildkraut, Joellen M

AU - Dobbins, Sara E

AU - Holroyd, Amy

AU - Calvocoressi, Lisa

AU - Lu, Lingeng

AU - Hansen, Helen M

AU - Smirnov, Ivan

AU - Walsh, Kyle M

AU - Schramm, Johannes

AU - Hoffmann, Per

AU - Nöthen, Markus M

AU - Jöckel, Karl-Heinz

AU - Swerdlow, Anthony

AU - Larsen, Signe Benzon

AU - Johansen, Christoffer

AU - Simon, Matthias

AU - Bondy, Melissa

AU - Wrensch, Margaret

AU - Houlston, Richard

AU - Wiemels, Joseph L

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Meningioma are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of two GWAS, imputed using a merged reference panel of 1,000 Genomes and UK10K data, with validation in two independent sample series totaling 2,138 cases and 12,081 controls.RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

AB - BACKGROUND: Meningioma are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of two GWAS, imputed using a merged reference panel of 1,000 Genomes and UK10K data, with validation in two independent sample series totaling 2,138 cases and 12,081 controls.RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

U2 - 10.1093/neuonc/noy077

DO - 10.1093/neuonc/noy077

M3 - Journal article

C2 - 29762745

VL - 20

SP - 1485

EP - 1493

JO - Neuro-Oncology

JF - Neuro-Oncology

SN - 1522-8517

IS - 11

ER -

ID: 54867062