Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Meningioma are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.
METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of two GWAS, imputed using a merged reference panel of 1,000 Genomes and UK10K data, with validation in two independent sample series totaling 2,138 cases and 12,081 controls.
RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.
CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.
| Original language | English |
|---|---|
| Journal | Neuro-Oncology |
| Volume | 20 |
| Issue number | 11 |
| Pages (from-to) | 1485-1493 |
| ISSN | 1522-8517 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
ID: 54867062