Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

R Alan Harris; Dorottya Nagy-Szakal; Natalia Pedersen; Antone Opekun; Jiri Bronsky; Pia Munkholm; Cathrine Jespersgaard; PaalSkytt Andersen; Bela Melegh; George Ferry; Tine Jess; Richard Kellermayer

doi:10.1002/ibd.22956

Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

R Alan Harris, Dorottya Nagy-Szakal, Natalia Pedersen, Antone Opekun, Jiri Bronsky, Pia Munkholm, Cathrine Jespersgaard, PaalSkytt Andersen, Bela Melegh, George Ferry, Tine Jess, Richard Kellermayer

Gastroenterology

67 Citations (Scopus)

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.

Original language	English
Journal	Inflammatory Bowel Diseases
Volume	18
Issue number	12
Pages (from-to)	2334-41
Number of pages	8
ISSN	1078-0998
DOIs	https://doi.org/10.1002/ibd.22956
Publication status	Published - 2012

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Harris, R. A., Nagy-Szakal, D., Pedersen, N., Opekun, A., Bronsky, J., Munkholm, P., Jespersgaard, C., Andersen, P., Melegh, B., Ferry, G., Jess, T., & Kellermayer, R. (2012). Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases. Inflammatory Bowel Diseases, 18(12), 2334-41. https://doi.org/10.1002/ibd.22956

Harris, RA, Nagy-Szakal, D, Pedersen, N, Opekun, A, Bronsky, J, Munkholm, P, Jespersgaard, C, Andersen, P, Melegh, B, Ferry, G, Jess, T & Kellermayer, R 2012, 'Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases', Inflammatory Bowel Diseases, vol. 18, no. 12, pp. 2334-41. https://doi.org/10.1002/ibd.22956

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title = "Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases",

abstract = "Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.",

author = "Harris, {R Alan} and Dorottya Nagy-Szakal and Natalia Pedersen and Antone Opekun and Jiri Bronsky and Pia Munkholm and Cathrine Jespersgaard and PaalSkytt Andersen and Bela Melegh and George Ferry and Tine Jess and Richard Kellermayer",

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AU - Harris, R Alan

AU - Nagy-Szakal, Dorottya

AU - Pedersen, Natalia

AU - Opekun, Antone

AU - Bronsky, Jiri

AU - Munkholm, Pia

AU - Jespersgaard, Cathrine

AU - Andersen, PaalSkytt

AU - Melegh, Bela

AU - Ferry, George

AU - Jess, Tine

AU - Kellermayer, Richard

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AB - Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.

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DO - 10.1002/ibd.22956

M3 - Journal article

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JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

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ER -

Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

Abstract

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