Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Henrik Berg Rasmussen; Christina Mackeprang Dahmcke

doi:10.1097/FPC.0b013e328352c770

Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Henrik Berg Rasmussen, Christina Mackeprang Dahmcke

7 Citations (Scopus)

Abstract

The objective of the present study was to identify structural variants of drug target-encoding genes on a genome-wide scale. We also aimed at identifying drugs that are potentially amenable for individualization of treatments based on knowledge about structural variation in the genes encoding their targets.

Original language	English
Journal	Pharmacogenetics and Genomics
Volume	22
Issue number	7
Pages (from-to)	471-83
Number of pages	13
ISSN	1744-6872
DOIs	https://doi.org/10.1097/FPC.0b013e328352c770
Publication status	Published - Jul 2012

Keywords

DNA Copy Number Variations
Databases, Factual
Genetic Variation
Genome, Human
Genomics
Humans
Pharmaceutical Preparations
Pharmacogenetics
Proteins
United States
United States Food and Drug Administration

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10.1097/FPC.0b013e328352c770

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abstract = "The objective of the present study was to identify structural variants of drug target-encoding genes on a genome-wide scale. We also aimed at identifying drugs that are potentially amenable for individualization of treatments based on knowledge about structural variation in the genes encoding their targets.",

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AU - Dahmcke, Christina Mackeprang

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KW - DNA Copy Number Variations

KW - Databases, Factual

KW - Genetic Variation

KW - Genome, Human

KW - Genomics

KW - Humans

KW - Pharmaceutical Preparations

KW - Pharmacogenetics

KW - Proteins

KW - United States

KW - United States Food and Drug Administration

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JO - Pharmacogenetics and Genomics

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ER -

Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Abstract

Keywords

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