Genome wide association study identifies KCNMA1 contributing to human obesity

Hong Jiao; Peter Arner; Johan Hoffstedt; David Brodin; Beatrice Dubern; Sébastien Czernichow; Ferdinand van't Hooft; Tomas Axelsson; Oluf Borbye Pedersen; Torben Hansen; Thorkild I A Sørensen; Johannes Hebebrand; Juha Kere; Karin Dahlman-Wright; Anders Hamsten; Karine Clement; Ingrid Dahlman

doi:10.1186/1755-8794-4-51

Genome wide association study identifies KCNMA1 contributing to human obesity

Hong Jiao, Peter Arner, Johan Hoffstedt, David Brodin, Beatrice Dubern, Sébastien Czernichow, Ferdinand van't Hooft, Tomas Axelsson, Oluf Borbye Pedersen, Torben Hansen, Thorkild I A Sørensen, Johannes Hebebrand, Juha Kere, Karin Dahlman-Wright, Anders Hamsten, Karine Clement, Ingrid Dahlman

82 Citations (Scopus)

Abstract

Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population. Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity.

Original language	English
Journal	B M C Medical Genomics
Volume	4
Pages (from-to)	51
ISSN	1755-8794
DOIs	https://doi.org/10.1186/1755-8794-4-51
Publication status	Published - 2011

Keywords

Alleles
Body Mass Index
Case-Control Studies
Cohort Studies
Female
France
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Germany
Humans
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
Male
Middle Aged
Obesity, Morbid
Polymorphism, Single Nucleotide
Sweden

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Jiao, H., Arner, P., Hoffstedt, J., Brodin, D., Dubern, B., Czernichow, S., van't Hooft, F., Axelsson, T., Pedersen, O. B., Hansen, T., Sørensen, T. I. A., Hebebrand, J., Kere, J., Dahlman-Wright, K., Hamsten, A., Clement, K., & Dahlman, I. (2011). Genome wide association study identifies KCNMA1 contributing to human obesity. B M C Medical Genomics, 4, 51. https://doi.org/10.1186/1755-8794-4-51

Jiao, H, Arner, P, Hoffstedt, J, Brodin, D, Dubern, B, Czernichow, S, van't Hooft, F, Axelsson, T, Pedersen, OB, Hansen, T, Sørensen, TIA, Hebebrand, J, Kere, J, Dahlman-Wright, K, Hamsten, A, Clement, K & Dahlman, I 2011, 'Genome wide association study identifies KCNMA1 contributing to human obesity', B M C Medical Genomics, vol. 4, pp. 51. https://doi.org/10.1186/1755-8794-4-51

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title = "Genome wide association study identifies KCNMA1 contributing to human obesity",

abstract = "Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population. Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity.",

keywords = "Alleles, Body Mass Index, Case-Control Studies, Cohort Studies, Female, France, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Germany, Humans, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits, Male, Middle Aged, Obesity, Morbid, Polymorphism, Single Nucleotide, Sweden",

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year = "2011",

doi = "10.1186/1755-8794-4-51",

language = "English",

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pages = "51",

journal = "B M C Medical Genomics",

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T1 - Genome wide association study identifies KCNMA1 contributing to human obesity

AU - Jiao, Hong

AU - Arner, Peter

AU - Hoffstedt, Johan

AU - Brodin, David

AU - Dubern, Beatrice

AU - Czernichow, Sébastien

AU - van't Hooft, Ferdinand

AU - Axelsson, Tomas

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

AU - Sørensen, Thorkild I A

AU - Hebebrand, Johannes

AU - Kere, Juha

AU - Dahlman-Wright, Karin

AU - Hamsten, Anders

AU - Clement, Karine

AU - Dahlman, Ingrid

PY - 2011

Y1 - 2011

N2 - Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population. Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity.

AB - Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population. Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity.

KW - Alleles

KW - Body Mass Index

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - France

KW - Genetic Predisposition to Disease

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Germany

KW - Humans

KW - Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

KW - Male

KW - Middle Aged

KW - Obesity, Morbid

KW - Polymorphism, Single Nucleotide

KW - Sweden

UR - https://www.scopus.com/pages/publications/79959601185

U2 - 10.1186/1755-8794-4-51

DO - 10.1186/1755-8794-4-51

M3 - Journal article

C2 - 21708048

SN - 1755-8794

VL - 4

SP - 51

JO - B M C Medical Genomics

JF - B M C Medical Genomics

ER -

Genome wide association study identifies KCNMA1 contributing to human obesity

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