Genetics of complex diseases: variations on a theme

Erling Mellerup, Gert Lykke Møller, Pernille Koefoed

3 Citations (Scopus)

Abstract

A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close to the number of patients suffering from the disease. This hypothesis is based on a study of bipolar disorder.
Original languageEnglish
JournalMedical Hypotheses
Volume78
Issue number6
Pages (from-to)732-4
Number of pages3
ISSN0306-9877
DOIs
Publication statusPublished - 2012

Keywords

  • Bipolar Disorder
  • Brain
  • Cell Communication
  • Genetic Diseases, Inborn
  • Genetic Variation
  • Genotype
  • Humans
  • Multifactorial Inheritance
  • Polymorphism, Single Nucleotide

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