Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk

Derek W Brown; Qing Lan; Nathaniel Rothman; John Pluta; Kristian Almstrup; Marlene D Dalgaard; Mark H Greene; Tom Grotmol; Chey Loveday; Stephen M Schwartz; Clare Turnbull; Fredrik Wiklund; Peter A Kanetsky; Katherine L Nathanson; Katherine A McGlynn; Mitchell J Machiela; Testicular Cancer Consortium

doi:10.1158/1055-9965.EPI-20-1775

Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk

Derek W Brown, Qing Lan, Nathaniel Rothman, John Pluta, Kristian Almstrup, Marlene D Dalgaard, Mark H Greene, Tom Grotmol, Chey Loveday, Stephen M Schwartz, Clare Turnbull, Fredrik Wiklund, Peter A Kanetsky, Katherine L Nathanson, Katherine A McGlynn, Mitchell J Machiela, Testicular Cancer Consortium

Department of Growth and Reproduction

5 Citations (Scopus)

Abstract

BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.

METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.

RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).

CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.

IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.

Original language	English
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume	30
Issue number	6
Pages (from-to)	1275-1278
Number of pages	4
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-20-1775
Publication status	Published - Jun 2021

Keywords

Case-Control Studies
Genetic Predisposition to Disease
Humans
Male
Mendelian Randomization Analysis
Neoplasms, Germ Cell and Embryonal/epidemiology
Risk Assessment/statistics & numerical data
Risk Factors
Telomere/metabolism
Telomere Homeostasis/genetics
Testicular Neoplasms/epidemiology

Access to Document

10.1158/1055-9965.EPI-20-1775

Cite this

Brown, D. W., Lan, Q., Rothman, N., Pluta, J., Almstrup, K., Dalgaard, M. D., Greene, M. H., Grotmol, T., Loveday, C., Schwartz, S. M., Turnbull, C., Wiklund, F., Kanetsky, P. A., Nathanson, K. L., McGlynn, K. A., Machiela, M. J., & Testicular Cancer Consortium (2021). Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(6), 1275-1278. https://doi.org/10.1158/1055-9965.EPI-20-1775

Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk. / Brown, Derek W; Lan, Qing; Rothman, Nathaniel et al.
In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 30, No. 6, 06.2021, p. 1275-1278.

Research output: Contribution to journal › Journal article › Research › peer-review

Brown, DW, Lan, Q, Rothman, N, Pluta, J, Almstrup, K, Dalgaard, MD, Greene, MH, Grotmol, T, Loveday, C, Schwartz, SM, Turnbull, C, Wiklund, F, Kanetsky, PA, Nathanson, KL, McGlynn, KA, Machiela, MJ & Testicular Cancer Consortium 2021, 'Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 30, no. 6, pp. 1275-1278. https://doi.org/10.1158/1055-9965.EPI-20-1775

Brown DW, Lan Q, Rothman N, Pluta J, Almstrup K, Dalgaard MD et al. Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Jun;30(6):1275-1278. doi: 10.1158/1055-9965.EPI-20-1775

@article{f65531348a5e441dab65afbe2b7583d4,

title = "Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk",

abstract = "BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95\% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.",

keywords = "Case-Control Studies, Genetic Predisposition to Disease, Humans, Male, Mendelian Randomization Analysis, Neoplasms, Germ Cell and Embryonal/epidemiology, Risk Assessment/statistics \& numerical data, Risk Factors, Telomere/metabolism, Telomere Homeostasis/genetics, Testicular Neoplasms/epidemiology",

author = "Brown, \{Derek W\} and Qing Lan and Nathaniel Rothman and John Pluta and Kristian Almstrup and Dalgaard, \{Marlene D\} and Greene, \{Mark H\} and Tom Grotmol and Chey Loveday and Schwartz, \{Stephen M\} and Clare Turnbull and Fredrik Wiklund and Kanetsky, \{Peter A\} and Nathanson, \{Katherine L\} and McGlynn, \{Katherine A\} and Machiela, \{Mitchell J\} and \{Testicular Cancer Consortium\}",

note = "{\textcopyright}2021 American Association for Cancer Research.",

year = "2021",

month = jun,

doi = "10.1158/1055-9965.EPI-20-1775",

language = "English",

volume = "30",

pages = "1275--1278",

journal = "Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "6",

}

TY - JOUR

T1 - Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk

AU - Brown, Derek W

AU - Lan, Qing

AU - Rothman, Nathaniel

AU - Pluta, John

AU - Almstrup, Kristian

AU - Dalgaard, Marlene D

AU - Greene, Mark H

AU - Grotmol, Tom

AU - Loveday, Chey

AU - Schwartz, Stephen M

AU - Turnbull, Clare

AU - Wiklund, Fredrik

AU - Kanetsky, Peter A

AU - Nathanson, Katherine L

AU - McGlynn, Katherine A

AU - Machiela, Mitchell J

AU - Testicular Cancer Consortium

PY - 2021/6

Y1 - 2021/6

N2 - BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.

AB - BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.

KW - Case-Control Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Mendelian Randomization Analysis

KW - Neoplasms, Germ Cell and Embryonal/epidemiology

KW - Risk Assessment/statistics & numerical data

KW - Risk Factors

KW - Telomere/metabolism

KW - Telomere Homeostasis/genetics

KW - Testicular Neoplasms/epidemiology

UR - https://www.scopus.com/pages/publications/85107007854

U2 - 10.1158/1055-9965.EPI-20-1775

DO - 10.1158/1055-9965.EPI-20-1775

M3 - Journal article

C2 - 33737296

SN - 1055-9965

VL - 30

SP - 1275

EP - 1278

JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

IS - 6

ER -

Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this