Genetically distinct subsets within ANCA-associated vasculitis

Paul A Lyons; Tim F Rayner; Sapna Trivedi; Julia U Holle; Richard A Watts; David R W Jayne; Bo Baslund; Paul Brenchley; Annette Bruchfeld; Afzal N Chaudhry; Jan Willem Cohen Tervaert; Panos Deloukas; Conleth Feighery; Wolfgang L Gross; Loic Guillevin; Iva Gunnarsson; Lorraine Harper; Zdenka Hrušková; Mark A Little; Davide Martorana; Thomas Neumann; Sophie Ohlsson; Sandosh Padmanabhan; Charles D Pusey; Alan D Salama; Jan-Stephan F Sanders; Caroline O Savage; Mårten Segelmark; Coen A Stegeman; Vladimir Tesař; Augusto Vaglio; Stefan Wieczorek; Benjamin Wilde; Jochen Zwerina; Andrew J Rees; David G Clayton; Kenneth G C Smith

doi:10.1056/NEJMoa1108735

Genetically distinct subsets within ANCA-associated vasculitis

Paul A Lyons, Tim F Rayner, Sapna Trivedi, Julia U Holle, Richard A Watts, David R W Jayne, Bo Baslund, Paul Brenchley, Annette Bruchfeld, Afzal N Chaudhry, Jan Willem Cohen Tervaert, Panos Deloukas, Conleth Feighery, Wolfgang L Gross, Loic Guillevin, Iva Gunnarsson, Lorraine Harper, Zdenka Hrušková, Mark A Little, Davide MartoranaThomas Neumann, Sophie Ohlsson, Sandosh Padmanabhan, Charles D Pusey, Alan D Salama, Jan-Stephan F Sanders, Caroline O Savage, Mårten Segelmark, Coen A Stegeman, Vladimir Tesař, Augusto Vaglio, Stefan Wieczorek, Benjamin Wilde, Jochen Zwerina, Andrew J Rees, David G Clayton, Kenneth G C Smith

881 Citations (Scopus)

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.

Original language	English
Journal	New England Journal of Medicine
Volume	367
Issue number	3
Pages (from-to)	214-23
Number of pages	10
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1108735
Publication status	Published - 2012

Keywords

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Case-Control Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotyping Techniques
HLA-DP Antigens
Humans
Major Histocompatibility Complex
Male
Microscopic Polyangiitis
Myeloblastin
Polymorphism, Single Nucleotide
Risk Factors
Wegener Granulomatosis
alpha 1-Antitrypsin

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Lyons, P. A., Rayner, T. F., Trivedi, S., Holle, J. U., Watts, R. A., Jayne, D. R. W., Baslund, B., Brenchley, P., Bruchfeld, A., Chaudhry, A. N., Cohen Tervaert, J. W., Deloukas, P., Feighery, C., Gross, W. L., Guillevin, L., Gunnarsson, I., Harper, L., Hrušková, Z., Little, M. A., ... Smith, K. G. C. (2012). Genetically distinct subsets within ANCA-associated vasculitis. New England Journal of Medicine, 367(3), 214-23. https://doi.org/10.1056/NEJMoa1108735

Lyons, PA, Rayner, TF, Trivedi, S, Holle, JU, Watts, RA, Jayne, DRW, Baslund, B, Brenchley, P, Bruchfeld, A, Chaudhry, AN, Cohen Tervaert, JW, Deloukas, P, Feighery, C, Gross, WL, Guillevin, L, Gunnarsson, I, Harper, L, Hrušková, Z, Little, MA, Martorana, D, Neumann, T, Ohlsson, S, Padmanabhan, S, Pusey, CD, Salama, AD, Sanders, J-SF, Savage, CO, Segelmark, M, Stegeman, CA, Tesař, V, Vaglio, A, Wieczorek, S, Wilde, B, Zwerina, J, Rees, AJ, Clayton, DG & Smith, KGC 2012, 'Genetically distinct subsets within ANCA-associated vasculitis', New England Journal of Medicine, vol. 367, no. 3, pp. 214-23. https://doi.org/10.1056/NEJMoa1108735

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abstract = "Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.",

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AU - Lyons, Paul A

AU - Rayner, Tim F

AU - Trivedi, Sapna

AU - Holle, Julia U

AU - Watts, Richard A

AU - Jayne, David R W

AU - Baslund, Bo

AU - Brenchley, Paul

AU - Bruchfeld, Annette

AU - Chaudhry, Afzal N

AU - Cohen Tervaert, Jan Willem

AU - Deloukas, Panos

AU - Feighery, Conleth

AU - Gross, Wolfgang L

AU - Guillevin, Loic

AU - Gunnarsson, Iva

AU - Harper, Lorraine

AU - Hrušková, Zdenka

AU - Little, Mark A

AU - Martorana, Davide

AU - Neumann, Thomas

AU - Ohlsson, Sophie

AU - Padmanabhan, Sandosh

AU - Pusey, Charles D

AU - Salama, Alan D

AU - Sanders, Jan-Stephan F

AU - Savage, Caroline O

AU - Segelmark, Mårten

AU - Stegeman, Coen A

AU - Tesař, Vladimir

AU - Vaglio, Augusto

AU - Wieczorek, Stefan

AU - Wilde, Benjamin

AU - Zwerina, Jochen

AU - Rees, Andrew J

AU - Clayton, David G

AU - Smith, Kenneth G C

PY - 2012

Y1 - 2012

N2 - Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.

AB - Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.

KW - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

KW - Case-Control Studies

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotyping Techniques

KW - HLA-DP Antigens

KW - Humans

KW - Major Histocompatibility Complex

KW - Male

KW - Microscopic Polyangiitis

KW - Myeloblastin

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Wegener Granulomatosis

KW - alpha 1-Antitrypsin

UR - https://www.scopus.com/pages/publications/84864014453

U2 - 10.1056/NEJMoa1108735

DO - 10.1056/NEJMoa1108735

M3 - Journal article

C2 - 22808956

SN - 0028-4793

VL - 367

SP - 214

EP - 223

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 3

ER -

Genetically distinct subsets within ANCA-associated vasculitis

Abstract

Keywords

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