Abstract
Patients with rheumatoid arthritis (RA) have excess morbidity and mortality due to ischemic heart disease. It has been suggested that high serum levels of mannose-binding lectin (MBL) and agalactosyl IgG (IgG-G0) are associated with increased inflammation in RA. MBL also enhances inflammation-mediated tissue injury during postischemic reperfusion. This study was undertaken to examine whether these factors are associated with increased risk of ischemic heart disease in RA.
| Original language | English |
|---|---|
| Journal | Arthritis & Rheumatism |
| Volume | 56 |
| Issue number | 1 |
| Pages (from-to) | 21-9 |
| Number of pages | 9 |
| ISSN | 0004-3591 |
| DOIs | |
| Publication status | Published - Jan 2007 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Rheumatoid
- Comorbidity
- Denmark
- Female
- Gene Frequency
- Genotype
- Humans
- Immunoglobulin G
- Male
- Mannose-Binding Lectin
- Middle Aged
- Myocardial Ischemia
- Polymorphism, Genetic
- Proportional Hazards Models
- Prospective Studies
- Survival Rate
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