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Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat

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This study was designed to investigate whether the genetic predisposition to insulin-dependent diabetes mellitus (IDDM) might be caused by an inherited increased sensitivity of the pancreatic B-cells to immune effector molecules e.g. the monokine interleukin 1 (IL-1), which is selectively cytotoxic to B-cells in vitro. Islets of Langerhans isolated from newborn diabetes prone and diabetes resistant Bio-Breeding rats, as well as from the inbred non-diabetic rat strains Wistar Furth, Brown-Norway and Lewis-Scripps were exposed to 0-1000 ng/l [corrected] of recombinant human IL-1 beta for 7 days. Strain-related differences in the sensitivity to IL-1 were studied by comparing the dose-responses of insulin release at 11 mmol/l glucose and islet light microscopic morphology to varying concentrations of IL-1. Statistical analyses showed a significant impact of strain on B-cell sensitivity to IL-1, Brown-Norway islets being relatively resistant to the action of IL-1. However, the the diabetes prone islets were not more sensitive to the cytotoxic effect of IL-1 than the non-diabetic control strain islets. We conclude that genetic differences in the response to IL-1 exist in vitro, but that this phenomenon is unrelated to the propensity to develop IDDM.

Original languageEnglish
JournalActa Endocrinologica
Volume120
Issue number1
Pages (from-to)92-8
Number of pages7
ISSN0001-5598
Publication statusPublished - Jan 1989
Externally publishedYes

    Research areas

  • Animals, Cells, Cultured, DNA, Diabetes Mellitus, Type 1, Insulin, Interleukin-1, Islets of Langerhans, Phenotype, Rats, Rats, Inbred BB, Rats, Inbred BN, Rats, Inbred Lew, Rats, Inbred Strains, Rats, Inbred WF, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

ID: 51782374