Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Celeste Leigh Pearce; Jennifer A Doherty; David J Van Den Berg; Kirsten Moysich; Chris Hsu; Kara L Cushing-Haugen; David V Conti; Susan J Ramus; Aleksandra Gentry-Maharaj; Usha Menon; Simon A Gayther; Paul D P Pharoah; Honglin Song; Susanne K Kjaer; Estrid Hogdall; Claus Hogdall; Alice S Whittemore; Valerie McGuire; Weiva Sieh; Jacek Gronwald; Krzysztof Medrek; Anna Jakubowska; Jan Lubinski; Georgia Chenevix-Trench; Jonathan Beesley; Penelope M Webb; Andrew Berchuck; Joellen M Schildkraut; Edwin S Iversen; Patricia G Moorman; Christopher K Edlund; Daniel O Stram; Malcolm C Pike; Roberta B Ness; Mary Anne Rossing; Anna H Wu; AOCS/ACS Study Group

doi:10.1093/hmg/ddr087

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Celeste Leigh Pearce, Jennifer A Doherty, David J Van Den Berg, Kirsten Moysich, Chris Hsu, Kara L Cushing-Haugen, David V Conti, Susan J Ramus, Aleksandra Gentry-Maharaj, Usha Menon, Simon A Gayther, Paul D P Pharoah, Honglin Song, Susanne K Kjaer, Estrid Hogdall, Claus Hogdall, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Jacek GronwaldKrzysztof Medrek, Anna Jakubowska, Jan Lubinski, Georgia Chenevix-Trench, Jonathan Beesley, Penelope M Webb, Andrew Berchuck, Joellen M Schildkraut, Edwin S Iversen, Patricia G Moorman, Christopher K Edlund, Daniel O Stram, Malcolm C Pike, Roberta B Ness, Mary Anne Rossing, Anna H Wu, AOCS/ACS Study Group

23 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P

Original language	English
Journal	Human Molecular Genetics
Volume	20
Issue number	11
Pages (from-to)	2263-72
Number of pages	10
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/ddr087
Publication status	Published - 1 Jun 2011

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Pearce, C. L., Doherty, J. A., Van Den Berg, D. J., Moysich, K., Hsu, C., Cushing-Haugen, K. L., Conti, D. V., Ramus, S. J., Gentry-Maharaj, A., Menon, U., Gayther, S. A., Pharoah, P. D. P., Song, H., Kjaer, S. K., Hogdall, E., Hogdall, C., Whittemore, A. S., McGuire, V., Sieh, W., ... AOCS/ACS Study Group (2011). Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. Human Molecular Genetics, 20(11), 2263-72. https://doi.org/10.1093/hmg/ddr087

Pearce, CL, Doherty, JA, Van Den Berg, DJ, Moysich, K, Hsu, C, Cushing-Haugen, KL, Conti, DV, Ramus, SJ, Gentry-Maharaj, A, Menon, U, Gayther, SA, Pharoah, PDP, Song, H, Kjaer, SK, Hogdall, E, Hogdall, C, Whittemore, AS, McGuire, V, Sieh, W, Gronwald, J, Medrek, K, Jakubowska, A, Lubinski, J, Chenevix-Trench, G, Beesley, J, Webb, PM, Berchuck, A, Schildkraut, JM, Iversen, ES, Moorman, PG, Edlund, CK, Stram, DO, Pike, MC, Ness, RB, Rossing, MA, Wu, AH & AOCS/ACS Study Group 2011, 'Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk', Human Molecular Genetics, vol. 20, no. 11, pp. 2263-72. https://doi.org/10.1093/hmg/ddr087

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title = "Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk",

abstract = "The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P",

author = "Pearce, {Celeste Leigh} and Doherty, {Jennifer A} and {Van Den Berg}, {David J} and Kirsten Moysich and Chris Hsu and Cushing-Haugen, {Kara L} and Conti, {David V} and Ramus, {Susan J} and Aleksandra Gentry-Maharaj and Usha Menon and Gayther, {Simon A} and Pharoah, {Paul D P} and Honglin Song and Kjaer, {Susanne K} and Estrid Hogdall and Claus Hogdall and Whittemore, {Alice S} and Valerie McGuire and Weiva Sieh and Jacek Gronwald and Krzysztof Medrek and Anna Jakubowska and Jan Lubinski and Georgia Chenevix-Trench and Jonathan Beesley and Webb, {Penelope M} and Andrew Berchuck and Schildkraut, {Joellen M} and Iversen, {Edwin S} and Moorman, {Patricia G} and Edlund, {Christopher K} and Stram, {Daniel O} and Pike, {Malcolm C} and Ness, {Roberta B} and Rossing, {Mary Anne} and Wu, {Anna H} and {AOCS/ACS Study Group}",

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AU - Pearce, Celeste Leigh

AU - Doherty, Jennifer A

AU - Van Den Berg, David J

AU - Moysich, Kirsten

AU - Hsu, Chris

AU - Cushing-Haugen, Kara L

AU - Conti, David V

AU - Ramus, Susan J

AU - Gentry-Maharaj, Aleksandra

AU - Menon, Usha

AU - Gayther, Simon A

AU - Pharoah, Paul D P

AU - Song, Honglin

AU - Kjaer, Susanne K

AU - Hogdall, Estrid

AU - Hogdall, Claus

AU - Whittemore, Alice S

AU - McGuire, Valerie

AU - Sieh, Weiva

AU - Gronwald, Jacek

AU - Medrek, Krzysztof

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Chenevix-Trench, Georgia

AU - Beesley, Jonathan

AU - Webb, Penelope M

AU - Berchuck, Andrew

AU - Schildkraut, Joellen M

AU - Iversen, Edwin S

AU - Moorman, Patricia G

AU - Edlund, Christopher K

AU - Stram, Daniel O

AU - Pike, Malcolm C

AU - Ness, Roberta B

AU - Rossing, Mary Anne

AU - Wu, Anna H

AU - AOCS/ACS Study Group

PY - 2011/6/1

Y1 - 2011/6/1

N2 - The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P

AB - The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P

U2 - 10.1093/hmg/ddr087

DO - 10.1093/hmg/ddr087

M3 - Journal article

C2 - 21422097

SN - 0964-6906

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SP - 2263

EP - 2272

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 11

ER -

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Abstract

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