Genetic Susceptibility to Sepsis: A Possible Role for Mannose-binding Lectin

Sepsis is an increasing problem in modern medicine and the leading cause of death in noncoronary intensive care unit patients. Over the past few years, several studies have provided data indicating that relatively common polymorphisms in genes encoding proteins of importance for innate immune recognition, the inflammatory response, and for coagulation and fibrinolysis, are associated with susceptibility for and outcome of sepsis. Recently, several studies have shed light on the importance of deficiency of mannose-binding lectin (MBL) as a susceptibility factor for sepsis. This review summarizes the evidence that critically ill patients carrying MBL-variant alleles may be at increased risk for severe sepsis. The prospect for the future is that genetic profiling may guide in identifying critically ill patients at increased risk for sepsis and poor outcome, and in tailoring a more individual and effective therapy.