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Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

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Harvard

Bauer, AE, Liu, X, Byrne, EM, Sullivan, PF, Wray, NR, Agerbo, E, Nyegaard, M, Grove, J, Musliner, KL, Ingstrup, KG, Johannsen, BMW, Mægbæk, ML, Wang, Y, Nordentoft, M, Mors, O, Børglum, AD, Werge, T, Hougaard, DM, Mortensen, PB, Munk-Olsen, T & Meltzer-Brody, S 2019, 'Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders' Translational psychiatry, vol. 9, no. 1, 288, pp. 288. https://doi.org/10.1038/s41398-019-0629-9

APA

Bauer, A. E., Liu, X., Byrne, E. M., Sullivan, P. F., Wray, N. R., Agerbo, E., ... Meltzer-Brody, S. (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational psychiatry, 9(1), 288. [288]. https://doi.org/10.1038/s41398-019-0629-9

CBE

Bauer AE, Liu X, Byrne EM, Sullivan PF, Wray NR, Agerbo E, Nyegaard M, Grove J, Musliner KL, Ingstrup KG, Johannsen BMW, Mægbæk ML, Wang Y, Nordentoft M, Mors O, Børglum AD, Werge T, Hougaard DM, Mortensen PB, Munk-Olsen T, Meltzer-Brody S. 2019. Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational psychiatry. 9(1):288. https://doi.org/10.1038/s41398-019-0629-9

MLA

Vancouver

Author

Bauer, Anna E ; Liu, Xiaoqin ; Byrne, Enda M ; Sullivan, Patrick F ; Wray, Naomi R ; Agerbo, Esben ; Nyegaard, Mette ; Grove, Jakob ; Musliner, Katherine L ; Ingstrup, Katja G ; Johannsen, Benedicte M W ; Mægbæk, Merete L ; Wang, Yunpeng ; Nordentoft, Merete ; Mors, Ole ; Børglum, Anders D ; Werge, Thomas ; Hougaard, David M ; Mortensen, Preben Bo ; Munk-Olsen, Trine ; Meltzer-Brody, Samantha. / Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. In: Translational psychiatry. 2019 ; Vol. 9, No. 1. pp. 288.

Bibtex

@article{e75577d8ffe04b0b838f03fa118382ea,
title = "Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders",
abstract = "Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95{\%} CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95{\%} CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95{\%} CI: 1.19-1.74) and without (OR, 1.88; 95{\%} CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.",
author = "Bauer, {Anna E} and Xiaoqin Liu and Byrne, {Enda M} and Sullivan, {Patrick F} and Wray, {Naomi R} and Esben Agerbo and Mette Nyegaard and Jakob Grove and Musliner, {Katherine L} and Ingstrup, {Katja G} and Johannsen, {Benedicte M W} and M{\ae}gb{\ae}k, {Merete L} and Yunpeng Wang and Merete Nordentoft and Ole Mors and B{\o}rglum, {Anders D} and Thomas Werge and Hougaard, {David M} and Mortensen, {Preben Bo} and Trine Munk-Olsen and Samantha Meltzer-Brody",
year = "2019",
month = "11",
day = "11",
doi = "10.1038/s41398-019-0629-9",
language = "English",
volume = "9",
pages = "288",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

AU - Bauer, Anna E

AU - Liu, Xiaoqin

AU - Byrne, Enda M

AU - Sullivan, Patrick F

AU - Wray, Naomi R

AU - Agerbo, Esben

AU - Nyegaard, Mette

AU - Grove, Jakob

AU - Musliner, Katherine L

AU - Ingstrup, Katja G

AU - Johannsen, Benedicte M W

AU - Mægbæk, Merete L

AU - Wang, Yunpeng

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Børglum, Anders D

AU - Werge, Thomas

AU - Hougaard, David M

AU - Mortensen, Preben Bo

AU - Munk-Olsen, Trine

AU - Meltzer-Brody, Samantha

PY - 2019/11/11

Y1 - 2019/11/11

N2 - Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

AB - Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

UR - http://www.scopus.com/inward/record.url?scp=85074863877&partnerID=8YFLogxK

U2 - 10.1038/s41398-019-0629-9

DO - 10.1038/s41398-019-0629-9

M3 - Journal article

VL - 9

SP - 288

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 288

ER -

ID: 58572484